Detailed information of TA system TA218336

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 970402..971173
• Replicon: chromosome
• Accession: NZ_CP084229
• Organism: Staphylococcus haemolyticus strain SE3.8

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: RES6_RS04915
• Protein ID: WP_141738627.1
• Coordinates: 971024..971173 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: RES6_RS04910
• Protein ID: WP_161511415.1
• Coordinates: 970402..971001 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RES6_RS04890 (RES6_004890)	966276..967730	+	1455	WP_161511412.1	ABC transporter substrate-binding protein/permease	-
RES6_RS04895 (RES6_004895)	967723..968445	+	723	WP_161511413.1	amino acid ABC transporter ATP-binding protein	-
RES6_RS04900 (RES6_004900)	968632..969759	+	1128	WP_161511414.1	tRNA epoxyqueuosine(34) reductase QueG	-
RES6_RS04905 (RES6_004905)	969760..970230	+	471	WP_053025428.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
RES6_RS04910 (RES6_004910)	970402..971001	+	600	WP_161511415.1	glucosamine-6-phosphate isomerase	Antitoxin
RES6_RS04915 (RES6_004915)	971024..971173	+	150	WP_141738627.1	SAS053 family protein	Toxin
RES6_RS04920 (RES6_004920)	971383..971778	+	396	WP_161511416.1	hypothetical protein	-
RES6_RS04925 (RES6_004925)	971983..973368	+	1386	WP_161511417.1	class II fumarate hydratase	-
RES6_RS04930 (RES6_004930)	973434..974258	-	825	WP_085060648.1	RluA family pseudouridine synthase	-
RES6_RS04935 (RES6_004935)	974446..975555	+	1110	WP_161511418.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5824.20 Da
• Isoelectric Point: 3.9484

>T218336 WP_141738627.1 NZ_CP084229:971024-971173 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDRLNQSHE

Nucleotide

• Length: 150 bp

>T218336 NZ_CP115837:c4578584-4578051 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22256.12 Da
• Isoelectric Point: 4.7588

>AT218336 WP_161511415.1 NZ_CP084229:970402-971001 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PASQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPADLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT218336 NZ_CP115837:c4578861-4578595 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA