Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 820391..820923 Replicon chromosome
Accession NZ_CP084229
Organism Staphylococcus haemolyticus strain SE3.8

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag RES6_RS04010 Protein ID WP_011275272.1
Coordinates 820558..820923 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2K0A6Q6
Locus tag RES6_RS04005 Protein ID WP_037538759.1
Coordinates 820391..820561 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RES6_RS03980 (RES6_003980) 816177..816656 + 480 WP_161511379.1 PH domain-containing protein -
RES6_RS03985 (RES6_003985) 816649..818172 + 1524 WP_161511380.1 PH domain-containing protein -
RES6_RS03990 (RES6_003990) 818165..818692 + 528 WP_037551985.1 PH domain-containing protein -
RES6_RS03995 (RES6_003995) 818702..819061 + 360 WP_037551987.1 holo-ACP synthase -
RES6_RS04000 (RES6_004000) 819157..820305 + 1149 WP_161511381.1 alanine racemase -
RES6_RS04005 (RES6_004005) 820391..820561 + 171 WP_037538759.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
RES6_RS04010 (RES6_004010) 820558..820923 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
RES6_RS04015 (RES6_004015) 821230..822231 + 1002 WP_085060547.1 PP2C family protein-serine/threonine phosphatase -
RES6_RS04020 (RES6_004020) 822330..822656 + 327 WP_011275274.1 anti-sigma factor antagonist -
RES6_RS04025 (RES6_004025) 822685..823137 + 453 WP_052071620.1 anti-sigma B factor RsbW -
RES6_RS04030 (RES6_004030) 823112..823882 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T218335 WP_011275272.1 NZ_CP084229:820558-820923 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

>T218335 NZ_CP115837:3977700-3977918 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT218335 WP_037538759.1 NZ_CP084229:820391-820561 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYIISNYKSE

Download         Length: 171 bp

>AT218335 NZ_CP115837:3977299-3977673 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAGGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2K0A6Q6

References