Detailed information of TA system TA218334

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 809375..809886
• Replicon: chromosome
• Accession: NZ_CP084229
• Organism: Staphylococcus haemolyticus strain SE3.8

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: A0A2K0A6P2
• Locus tag: RES6_RS03950
• Protein ID: WP_037551971.1
• Coordinates: 809680..809886 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: RES6_RS03945
• Protein ID: WP_037538785.1
• Coordinates: 809375..809668 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RES6_RS03920 (RES6_003920)	804502..805293	+	792	WP_161511383.1	hydroxyethylthiazole kinase	-
RES6_RS03925 (RES6_003925)	805295..805933	+	639	WP_085060557.1	thiamine phosphate synthase	-
RES6_RS03930 (RES6_003930)	806022..806897	+	876	WP_161511375.1	membrane protein insertase YidC	-
RES6_RS03935 (RES6_003935)	806962..807603	-	642	WP_085060556.1	HD domain-containing protein	-
RES6_RS03940 (RES6_003940)	807703..809187	-	1485	WP_161511376.1	cardiolipin synthase	-
RES6_RS03945 (RES6_003945)	809375..809668	+	294	WP_037538785.1	copper-sensing transcriptional repressor CsoR	Antitoxin
RES6_RS03950 (RES6_003950)	809680..809886	+	207	WP_037551971.1	heavy-metal-associated domain-containing protein	Toxin
RES6_RS03955 (RES6_003955)	809994..810131	+	138	WP_011275260.1	Lmo0850 family protein	-
RES6_RS03960 (RES6_003960)	810180..811370	-	1191	WP_037551974.1	FtsW/RodA/SpoVE family cell cycle protein	-
RES6_RS03965 (RES6_003965)	811788..812858	+	1071	WP_053025522.1	D-alanine--D-alanine ligase	-
RES6_RS03970 (RES6_003970)	812874..814229	+	1356	WP_161511377.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (15-92)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7841.79 Da
• Isoelectric Point: 4.0742

>T218334 WP_037551971.1 NZ_CP084229:809680-809886 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISFETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T218334 NZ_CP115837:c2639823-2638501 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACACTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGTCCAATGCGACGGTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11236.86 Da
• Isoelectric Point: 6.6364

>AT218334 WP_037538785.1 NZ_CP084229:809375-809668 [Staphylococcus haemolyticus]
MNNHENAHHSEQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT218334 NZ_CP115837:c2640089-2639823 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Toxin

• AlphaFold DB: A0A2K0A6P2