Detailed information of TA system TA218330

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 38007..38542
• Replicon: plasmid pArsBee1
• Accession: NZ_CP084223
• Organism: Arsenophonus apicola strain ArsBeeUS

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LDL57_RS15800
• Protein ID: WP_180559005.1
• Coordinates: 38255..38542 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4V1BXI0
• Locus tag: LDL57_RS15795
• Protein ID: WP_026824096.1
• Coordinates: 38007..38258 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDL57_RS15765 (LDL57_15765)	33734..34171	-	438	WP_225507748.1	lytic transglycosylase domain-containing protein	-
LDL57_RS15770 (LDL57_15770)	34313..35074	-	762	WP_180559740.1	IS21-like element helper ATPase IstB	-
LDL57_RS15775 (LDL57_15775)	35061..36101	-	1041	WP_180559741.1	IS21 family transposase	-
LDL57_RS15780 (LDL57_15780)	36215..36793	-	579	WP_225507731.1	type 4 pilus major pilin	-
LDL57_RS15785 (LDL57_15785)	36829..37281	-	453	WP_225507733.1	type II secretion system F family protein	-
LDL57_RS15790 (LDL57_15790)	37289..37924	-	636	WP_225507735.1	type II secretion system F family protein	-
LDL57_RS15795 (LDL57_15795)	38007..38258	+	252	WP_026824096.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LDL57_RS15800 (LDL57_15800)	38255..38542	+	288	WP_180559005.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LDL57_RS15805 (LDL57_15805)	38554..40062	-	1509	WP_180559006.1	ATPase, T2SS/T4P/T4SS family	-
LDL57_RS15810 (LDL57_15810)	40077..40550	-	474	WP_180559007.1	type IV pilus biogenesis protein PilP	-
LDL57_RS15815 (LDL57_15815)	40537..41805	-	1269	WP_225507737.1	type 4b pilus protein PilO2	-
LDL57_RS15820 (LDL57_15820)	41814..43436	-	1623	WP_225507738.1	PilN family type IVB pilus formation outer membrane protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..94565	94565

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11137.23 Da
• Isoelectric Point: 11.0113

>T218330 WP_180559005.1 NZ_CP084223:38255-38542 [Arsenophonus apicola]
MIHKVKFRTDALKEWNSLDRSIQQQFARKLKKCAENPHIPAARLKGMQNCYKIKLRSSGFRLVYQIIKDELIIAVVAVGK
REHSEVYKLASKRLR

Nucleotide

• Length: 288 bp

>T218330 NZ_CP115837:1443698-1444114 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGACCGGATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATCCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCTGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCTATCGCGGCCGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTAAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9362.58 Da
• Isoelectric Point: 4.0543

>AT218330 WP_026824096.1 NZ_CP084223:38007-38258 [Arsenophonus apicola]
MPTTILSTTTASITELKTNPMATVNSGDGYPVAILNRNQPAFYCIPAELYEQMLEFIDDQELANLVKERAEQTLHDVNLD
RYL

Nucleotide

• Length: 252 bp

>AT218330 NZ_CP115837:1443471-1443701 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCTGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Structures

Antitoxin

• AlphaFold DB: A0A4V1BXI0