Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /DUF1778(antitoxin) |
| Location | 4513020..4513816 | Replicon | chromosome |
| Accession | NC_008750 | ||
| Organism | Shewanella sp. W3-18-1 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A6N3J9I8 |
| Locus tag | SPUTW3181_RS20415 | Protein ID | WP_011791158.1 |
| Coordinates | 4513020..4513550 (-) | Length | 177 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6N3J9J2 |
| Locus tag | SPUTW3181_RS20420 | Protein ID | WP_011791159.1 |
| Coordinates | 4513547..4513816 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SPUTW3181_RS20390 | 4508571..4509344 | + | 774 | WP_011791155.1 | hypothetical protein | - |
| SPUTW3181_RS20395 | 4509619..4510089 | + | 471 | WP_011791156.1 | hypothetical protein | - |
| SPUTW3181_RS20400 | 4510152..4510544 | + | 393 | Protein_3919 | hypothetical protein | - |
| SPUTW3181_RS20405 | 4510683..4512293 | + | 1611 | WP_011787758.1 | IS1634-like element ISSpu7 family transposase | - |
| SPUTW3181_RS20410 | 4512315..4512611 | + | 297 | Protein_3921 | hypothetical protein | - |
| SPUTW3181_RS20415 | 4513020..4513550 | - | 531 | WP_011791158.1 | GNAT family N-acetyltransferase | Toxin |
| SPUTW3181_RS20420 | 4513547..4513816 | - | 270 | WP_011791159.1 | DUF1778 domain-containing protein | Antitoxin |
| SPUTW3181_RS20425 | 4514193..4514747 | - | 555 | WP_011791160.1 | transglycosylase domain-containing protein | - |
| SPUTW3181_RS20430 | 4515123..4515347 | - | 225 | WP_025007977.1 | hypothetical protein | - |
| SPUTW3181_RS20435 | 4515703..4516395 | - | 693 | WP_025007976.1 | hypothetical protein | - |
| SPUTW3181_RS21930 | 4516733..4516873 | - | 141 | WP_157037401.1 | hypothetical protein | - |
| SPUTW3181_RS20440 | 4516903..4517286 | - | 384 | WP_011791162.1 | GIY-YIG nuclease family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 4510683..4512293 | 1610 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 177 a.a. Molecular weight: 19795.16 Da Isoelectric Point: 8.3330
>T21833 WP_011791158.1 NC_008750:c4513550-4513020 [Shewanella sp. W3-18-1]
VSYSKIFKELDKSLHDRVSFDCGEAELNDFIQTQAAKHMQAGISRTMVLPAAMPLPNQKYPICSFYTIAPSSICRDTLPQ
AIGKKLPRYPIPVFLLAQLAVHKEFHGSGLGKASLIKALEYLWEINAHMRAYAIVVDCLTDQAESFYAKYGFEVLCEING
RVRMFIPMKTVGQLFT
VSYSKIFKELDKSLHDRVSFDCGEAELNDFIQTQAAKHMQAGISRTMVLPAAMPLPNQKYPICSFYTIAPSSICRDTLPQ
AIGKKLPRYPIPVFLLAQLAVHKEFHGSGLGKASLIKALEYLWEINAHMRAYAIVVDCLTDQAESFYAKYGFEVLCEING
RVRMFIPMKTVGQLFT
Download Length: 531 bp
>T21833 NC_008750:c4513550-4513020 [Shewanella sp. W3-18-1]
GTGAGTTATTCCAAAATTTTCAAAGAATTGGATAAATCACTACACGATAGAGTATCATTTGACTGTGGCGAAGCAGAGTT
AAACGATTTTATCCAAACTCAAGCAGCAAAACATATGCAAGCAGGTATTAGCCGTACAATGGTTTTACCTGCTGCTATGC
CATTGCCCAATCAAAAATATCCAATTTGCTCATTTTATACTATCGCACCAAGTTCAATTTGCCGTGATACCTTGCCGCAA
GCTATTGGCAAAAAGTTACCACGCTATCCCATTCCGGTCTTTCTGCTTGCTCAACTTGCGGTTCATAAAGAGTTTCATGG
CAGTGGGTTAGGTAAAGCTAGCTTAATCAAAGCACTAGAATATCTGTGGGAAATTAACGCTCACATGAGAGCTTATGCCA
TTGTTGTCGATTGCTTAACTGACCAAGCTGAATCATTCTACGCAAAATATGGTTTCGAGGTTCTTTGTGAAATCAACGGT
CGTGTCAGAATGTTTATTCCAATGAAAACAGTCGGTCAGTTATTCACTTAG
GTGAGTTATTCCAAAATTTTCAAAGAATTGGATAAATCACTACACGATAGAGTATCATTTGACTGTGGCGAAGCAGAGTT
AAACGATTTTATCCAAACTCAAGCAGCAAAACATATGCAAGCAGGTATTAGCCGTACAATGGTTTTACCTGCTGCTATGC
CATTGCCCAATCAAAAATATCCAATTTGCTCATTTTATACTATCGCACCAAGTTCAATTTGCCGTGATACCTTGCCGCAA
GCTATTGGCAAAAAGTTACCACGCTATCCCATTCCGGTCTTTCTGCTTGCTCAACTTGCGGTTCATAAAGAGTTTCATGG
CAGTGGGTTAGGTAAAGCTAGCTTAATCAAAGCACTAGAATATCTGTGGGAAATTAACGCTCACATGAGAGCTTATGCCA
TTGTTGTCGATTGCTTAACTGACCAAGCTGAATCATTCTACGCAAAATATGGTTTCGAGGTTCTTTGTGAAATCAACGGT
CGTGTCAGAATGTTTATTCCAATGAAAACAGTCGGTCAGTTATTCACTTAG
Antitoxin
Download Length: 90 a.a. Molecular weight: 9859.32 Da Isoelectric Point: 4.7037
>AT21833 WP_011791159.1 NC_008750:c4513816-4513547 [Shewanella sp. W3-18-1]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATQVIAEHESVTVKADVFDQFIMACDEAKVPNKALREAA
AFTKNGEFK
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATQVIAEHESVTVKADVFDQFIMACDEAKVPNKALREAA
AFTKNGEFK
Download Length: 270 bp
>AT21833 NC_008750:c4513816-4513547 [Shewanella sp. W3-18-1]
ATGGCGACTGCAAGACTTGATATCCGTTTGGATGAAGAAATCAAAGCTAAGGCTGAGAAAGCATCCGCTTTGCTCGGGTT
AAAAAGCTTAACTGAATACGTTGTTCGCTTAATGGACGAAGATGCAACTCAGGTGATAGCTGAGCATGAAAGCGTTACGG
TTAAAGCAGATGTATTCGACCAATTCATAATGGCTTGTGATGAGGCTAAGGTTCCGAATAAGGCATTGCGTGAAGCGGCT
GCATTTACTAAAAATGGTGAGTTTAAGTGA
ATGGCGACTGCAAGACTTGATATCCGTTTGGATGAAGAAATCAAAGCTAAGGCTGAGAAAGCATCCGCTTTGCTCGGGTT
AAAAAGCTTAACTGAATACGTTGTTCGCTTAATGGACGAAGATGCAACTCAGGTGATAGCTGAGCATGAAAGCGTTACGG
TTAAAGCAGATGTATTCGACCAATTCATAATGGCTTGTGATGAGGCTAAGGTTCCGAATAAGGCATTGCGTGAAGCGGCT
GCATTTACTAAAAATGGTGAGTTTAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6N3J9I8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6N3J9J2 |