Detailed information of TA system TA218329

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2429449..2430103
• Replicon: chromosome
• Accession: NZ_CP084222
• Organism: Arsenophonus apicola strain ArsBeeUS

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LDL57_RS11530
• Protein ID: WP_180558768.1
• Coordinates: 2429449..2429856 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A4P7KWA0
• Locus tag: LDL57_RS11535
• Protein ID: WP_026821812.1
• Coordinates: 2429837..2430103 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDL57_RS11510 (LDL57_11510)	2424574..2425485	-	912	WP_180558772.1	site-specific tyrosine recombinase XerD	-
LDL57_RS11515 (LDL57_11515)	2425977..2426150	+	174	WP_180558771.1	hypothetical protein	-
LDL57_RS11520 (LDL57_11520)	2427130..2428443	+	1314	WP_180558770.1	S8 family serine peptidase	-
LDL57_RS11525 (LDL57_11525)	2428915..2429433	+	519	WP_180558769.1	flavodoxin FldB	-
LDL57_RS11530 (LDL57_11530)	2429449..2429856	-	408	WP_180558768.1	protein YgfX	Toxin
LDL57_RS11535 (LDL57_11535)	2429837..2430103	-	267	WP_026821812.1	FAD assembly factor SdhE	Antitoxin
LDL57_RS11540 (LDL57_11540)	2430363..2431349	+	987	WP_180558767.1	tRNA-modifying protein YgfZ	-
LDL57_RS11545 (LDL57_11545)	2432215..2432541	-	327	WP_180558765.1	hypothetical protein	-
LDL57_RS11550 (LDL57_11550)	2432793..2433629	-	837	WP_180558764.1	hypothetical protein	-
LDL57_RS11555 (LDL57_11555)	2433722..2434579	-	858	WP_180558763.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15888.82 Da
• Isoelectric Point: 10.8101

>T218329 WP_180558768.1 NZ_CP084222:c2429856-2429449 [Arsenophonus apicola]
VVLWKFNINVSWLTQLFSTGVHVGIGLLVFFSSWPPNNLVTWLIATLLIVASWVRSQKNISRCKGSLVLLNGNKIQWKKS
EWLIVKKPWFCFFGVKLTLRSWQCNKRIRLWIASDSMPEEEWRNLNQLLLQYPDI

Nucleotide

• Length: 408 bp

>T218329 NZ_CP115837:802832-803242 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10612.15 Da
• Isoelectric Point: 5.1149

>AT218329 WP_026821812.1 NZ_CP084222:c2430103-2429837 [Arsenophonus apicola]
MDINHKPRIHWACRRGMRELDIAIMPFFEYEYDSLTEDEKCLFVRLLECADPDLFNWLMNHGRPDDDGLYHMIQLIQSRN
KQRGSLEI

Nucleotide

• Length: 267 bp

>AT218329 NZ_CP115837:802585-802851 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A4P7KWA0