Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 1246168..1246747 Replicon chromosome
Accession NZ_CP084222
Organism Arsenophonus apicola strain ArsBeeUS

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag LDL57_RS05720 Protein ID WP_180560177.1
Coordinates 1246454..1246747 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag LDL57_RS05715 Protein ID WP_180560176.1
Coordinates 1246168..1246473 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDL57_RS05695 (LDL57_05695) 1241253..1242365 - 1113 WP_180560174.1 phage major capsid protein, P2 family -
LDL57_RS05700 (LDL57_05700) 1242376..1243197 - 822 WP_225507259.1 GPO family capsid scaffolding protein -
LDL57_RS05705 (LDL57_05705) 1243348..1245084 + 1737 WP_180560251.1 terminase family protein -
LDL57_RS05710 (LDL57_05710) 1245086..1246111 + 1026 WP_180560175.1 phage portal protein -
LDL57_RS05715 (LDL57_05715) 1246168..1246473 - 306 WP_180560176.1 BrnA antitoxin family protein Antitoxin
LDL57_RS05720 (LDL57_05720) 1246454..1246747 - 294 WP_180560177.1 BrnT family toxin Toxin
LDL57_RS05725 (LDL57_05725) 1246823..1246981 - 159 WP_180560178.1 hypothetical protein -
LDL57_RS05730 (LDL57_05730) 1247604..1247852 - 249 WP_180560179.1 hypothetical protein -
LDL57_RS05735 (LDL57_05735) 1248193..1250835 - 2643 WP_180560180.1 toprim domain-containing protein -
LDL57_RS17720 1250840..1250971 - 132 WP_255498994.1 hypothetical protein -
LDL57_RS05740 (LDL57_05740) 1250968..1251195 - 228 WP_180560181.1 TraR/DksA family transcriptional regulator -
LDL57_RS05745 (LDL57_05745) 1251188..1251403 - 216 WP_180560182.1 DUF2732 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1216736..1263027 46291


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11408.86 Da        Isoelectric Point: 7.4216

>T218325 WP_180560177.1 NZ_CP084222:c1246747-1246454 [Arsenophonus apicola]
MSLQFEWDPEKSASNLKKHGIRFEEAAQVFNDPMHLSHQDRFENGELRWQTIGQVGGCIIVFVAHTINFENSVEIIRIIS
ARRATRAERKHYEKSYY

Download         Length: 294 bp

>T218325 NZ_CP115833:c16527-16111 [Klebsiella pneumoniae]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11501.37 Da        Isoelectric Point: 10.8262

>AT218325 WP_180560176.1 NZ_CP084222:c1246473-1246168 [Arsenophonus apicola]
MKKVTIKQNALPTLTDKRKAELKVLAGMPESEINFSDIPPMDEVTWQNAHRGNFYRPIKQHASVRIDADVLAWLRGSGKG
YQTRLNAILRAAMLKDLNNKR

Download         Length: 306 bp

>AT218325 NZ_CP115833:c16754-16524 [Klebsiella pneumoniae]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References