Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 46631..48254 Replicon plasmid unnamed1
Accession NZ_CP084217
Organism Salmonella sp. JXY0409-18

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag LDB27_RS22600 Protein ID WP_000088046.1
Coordinates 46631..47956 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag LDB27_RS22605 Protein ID WP_024136327.1
Coordinates 47961..48254 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB27_RS22560 (LDB27_22560) 41652..42008 + 357 WP_065311124.1 H-NS family nucleoid-associated regulatory protein -
LDB27_RS22565 (LDB27_22565) 42350..42553 - 204 WP_001194555.1 hypothetical protein -
LDB27_RS22570 (LDB27_22570) 42615..43472 - 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
LDB27_RS22575 (LDB27_22575) 43488..43796 - 309 WP_001224687.1 hypothetical protein -
LDB27_RS22580 (LDB27_22580) 44345..44770 - 426 WP_001043843.1 hypothetical protein -
LDB27_RS22585 (LDB27_22585) 45024..45839 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
LDB27_RS22590 (LDB27_22590) 45852..46262 - 411 WP_000985911.1 hypothetical protein -
LDB27_RS22595 (LDB27_22595) 46364..46570 - 207 WP_000134171.1 hypothetical protein -
LDB27_RS22600 (LDB27_22600) 46631..47956 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
LDB27_RS22605 (LDB27_22605) 47961..48254 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
LDB27_RS22610 (LDB27_22610) 48858..49250 - 393 WP_000341066.1 hypothetical protein -
LDB27_RS22615 (LDB27_22615) 49623..49964 + 342 WP_001151575.1 hypothetical protein -
LDB27_RS22620 (LDB27_22620) 50056..50247 + 192 WP_000398480.1 hypothetical protein -
LDB27_RS22625 (LDB27_22625) 50297..50578 + 282 WP_000077926.1 hypothetical protein -
LDB27_RS23860 50919..51050 - 132 WP_000374059.1 hypothetical protein -
LDB27_RS22630 (LDB27_22630) 51141..52382 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / aph(6)-Id / floR / aph(3')-Ia / dfrA14 / ARR-3 / mph(A) / qnrS1 / blaCTX-M-55 / blaTEM-1B / blaLAP-2 / aac(3)-IId / ant(3'')-Ia / lnu(F) - 1..263947 263947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T218323 WP_000088046.1 NZ_CP084217:c47956-46631 [Salmonella sp. JXY0409-18]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T218323 NZ_CP115832:c28296-27826 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCATGGACCGGATATGGTGCGAAAGAGGCTGGTGGACG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT218323 WP_024136327.1 NZ_CP084217:c48254-47961 [Salmonella sp. JXY0409-18]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT218323 NZ_CP115832:c28736-28293 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTTGACGGGAAGGTGGCGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCTGAACAA
AGTGAACGTCTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACGGGAGCGTATGAGA
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References