Detailed information of TA system TA218320

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4113418..4114199
• Replicon: chromosome
• Accession: NZ_CP084216
• Organism: Salmonella sp. JXY0409-18

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: A0A752VN12
• Locus tag: LDB27_RS20090
• Protein ID: WP_000622305.1
• Coordinates: 4113418..4113909 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A3V4SIN7
• Locus tag: LDB27_RS20095
• Protein ID: WP_001110453.1
• Coordinates: 4113906..4114199 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDB27_RS20065 (4108553)	4108553..4110991	-	2439	WP_001014136.1	F4 (K88) fimbrial usher FaeD	-
LDB27_RS20070 (4111001)	4111001..4111540	-	540	WP_000721295.1	type 1 fimbrial protein	-
LDB27_RS20075 (4111575)	4111575..4111859	-	285	WP_192917775.1	PapB/FocB family fimbrial expression transcriptional regulator	-
LDB27_RS20080 (4112448)	4112448..4112675	+	228	WP_001112995.1	hypothetical protein	-
LDB27_RS20085 (4112950)	4112950..4113183	-	234	Protein_3923	IS481 family transposase	-
LDB27_RS20090 (4113418)	4113418..4113909	-	492	WP_000622305.1	GNAT family N-acetyltransferase	Toxin
LDB27_RS20095 (4113906)	4113906..4114199	-	294	WP_001110453.1	DUF1778 domain-containing protein	Antitoxin
LDB27_RS20100 (4114516)	4114516..4114738	+	223	Protein_3926	hypothetical protein	-
LDB27_RS20105 (4115002)	4115002..4115877	+	876	WP_000921676.1	AraC family transcriptional regulator	-
LDB27_RS20110 (4115874)	4115874..4116161	+	288	WP_001269916.1	transcriptional regulator RtsB	-
LDB27_RS20115 (4116154)	4116154..4116336	-	183	WP_001527266.1	ATP-binding cassette domain-containing protein	-
LDB27_RS20120 (4116356)	4116356..4116455	+	100	Protein_3930	hypothetical protein	-
LDB27_RS20125 (4116565)	4116565..4116699	+	135	Protein_3931	hypothetical protein	-
LDB27_RS20130 (4116994)	4116994..4117899	-	906	WP_225519891.1	YjiK family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	faeI / faeH / faeF / faeE / faeD / faeC	4101796..4116336	14540

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (87-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-95)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17606.43 Da
• Isoelectric Point: 7.7297

>T218320 WP_000622305.1 NZ_CP084216:c4113909-4113418 [Salmonella sp. JXY0409-18]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Nucleotide

• Length: 492 bp

>T218320 NZ_CP115831:c4734711-4734427 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCTGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10948.57 Da
• Isoelectric Point: 9.8590

>AT218320 WP_001110453.1 NZ_CP084216:c4114199-4113906 [Salmonella sp. JXY0409-18]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT218320 NZ_CP115831:c4734943-4734701 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A752VN12

Antitoxin

• AlphaFold DB: A0A3V4SIN7