Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 335704..337493 Replicon chromosome
Accession NC_008750
Organism Shewanella sp. W3-18-1

Toxin (Protein)


Gene name hipA Uniprot ID A0A6N3J0D2
Locus tag SPUTW3181_RS01605 Protein ID WP_011787706.1
Coordinates 335704..337050 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag SPUTW3181_RS01610 Protein ID WP_011787707.1
Coordinates 337047..337493 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPUTW3181_RS01590 331152..331865 + 714 WP_011787702.1 MarC family NAAT transporter -
SPUTW3181_RS01595 331982..333427 - 1446 WP_011787703.1 DUF4892 domain-containing protein -
SPUTW3181_RS21410 333580..333933 + 354 WP_011787704.1 hypothetical protein -
SPUTW3181_RS21415 333917..334012 + 96 WP_081429771.1 response regulator transcription factor -
SPUTW3181_RS01600 334488..334844 + 357 WP_011787705.1 hypothetical protein -
SPUTW3181_RS01605 335704..337050 + 1347 WP_011787706.1 type II toxin-antitoxin system HipA family toxin Toxin
SPUTW3181_RS01610 337047..337493 + 447 WP_011787707.1 helix-turn-helix domain-containing protein Antitoxin
SPUTW3181_RS21945 337490..337798 - 309 Protein_308 DUF3387 domain-containing protein -
SPUTW3181_RS21950 337784..337981 - 198 Protein_309 transposase -
SPUTW3181_RS01620 338036..338317 - 282 WP_011787709.1 type II toxin-antitoxin system HicB family antitoxin -
SPUTW3181_RS01625 338408..338824 - 417 WP_011787710.1 DNA-binding protein -
SPUTW3181_RS01630 339168..340421 - 1254 WP_011787711.1 50S ribosome-binding GTPase -
SPUTW3181_RS01635 340479..340844 - 366 WP_011787712.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-380)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-139)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 51078.94 Da        Isoelectric Point: 4.7439

>T21832 WP_011787706.1 NC_008750:335704-337050 [Shewanella sp. W3-18-1]
MEQLTIQAYINGQWSDIAQLSFPESEQGNYRLTSLDYEQAYALAELDKDDLHAVSLNHPVSLFFDDLGRPGWLRFLDDIM
PSGASRRYWLKYLDIADLTLDEQNFVLLKFGTIAPVGNLRVKESLPKRTAIADTLKFTVDDVRNRAADFLDYAQHRGAAA
GGATGAGGEAPKLLLRCDDEQNIWIDSYQDEPQNRDLHYLVKYPRGARLPIDCDILRAEYHYYHELAEMGFETIPTANMR
LEEGHSYPSLWLPRFDIYFNELGQQRYAMESVYSILGKGAGVTLDHEQTIRALIDKITHSHMVLEQGYQFDVRAFVIEWV
RRDLLNILFGNSDNHGRNTAFLRGDGWIRLAPIYDFAPMKADPEGIARTTKWEAPLEIGGEYDFLGIAEVLTDLVPAQEL
LIDLKRTAQQCLGLKQRLIERGVPLRIIDMPAIGFAYLEDKLTRWGLA

Download         Length: 1347 bp

>T21832 NC_008750:335704-337050 [Shewanella sp. W3-18-1]
ATGGAACAGTTGACCATTCAGGCGTACATTAATGGCCAATGGAGCGATATTGCACAGCTCTCATTCCCTGAGAGCGAACA
AGGTAATTATCGGCTTACCTCGTTAGATTACGAGCAAGCATATGCATTAGCTGAGCTAGATAAAGACGACTTGCACGCCG
TCTCGCTAAACCATCCTGTTAGCCTTTTTTTCGACGATCTAGGTAGACCAGGATGGTTACGCTTTCTTGATGACATCATG
CCTAGCGGCGCAAGCCGTCGCTATTGGCTTAAGTATTTAGATATCGCAGACCTGACCTTAGACGAGCAAAATTTTGTACT
TTTGAAGTTTGGGACCATCGCTCCCGTGGGTAATTTGCGGGTAAAGGAATCTTTGCCTAAGCGCACCGCTATCGCTGATA
CACTGAAATTCACCGTAGACGACGTTAGGAATCGAGCTGCTGACTTTTTGGATTATGCGCAACATCGAGGCGCTGCCGCT
GGTGGCGCAACAGGGGCTGGCGGCGAAGCGCCCAAGCTTTTGTTACGTTGCGACGATGAGCAAAATATCTGGATTGATAG
CTATCAAGACGAACCGCAAAACCGTGACCTTCATTATCTGGTGAAATACCCAAGAGGCGCTCGGTTGCCTATTGACTGCG
ATATCTTACGCGCGGAATACCACTATTATCACGAATTGGCTGAAATGGGCTTTGAGACCATTCCTACGGCTAATATGCGG
CTCGAAGAAGGCCATTCCTACCCATCGCTATGGTTGCCGCGCTTTGATATTTACTTCAACGAACTAGGCCAACAACGTTA
TGCGATGGAGTCGGTCTATTCGATTTTGGGTAAAGGCGCGGGCGTTACCTTAGACCATGAGCAAACCATAAGAGCGTTGA
TCGATAAAATCACTCATAGCCATATGGTCTTAGAGCAAGGTTATCAGTTTGATGTGCGTGCTTTTGTCATTGAGTGGGTG
CGGCGAGACTTACTCAATATCCTATTTGGCAATAGTGATAATCACGGGCGTAATACCGCGTTTCTTAGGGGCGATGGTTG
GATAAGGCTTGCGCCTATCTATGACTTTGCACCGATGAAAGCTGACCCAGAAGGCATAGCTAGAACCACAAAGTGGGAAG
CCCCGCTTGAAATCGGGGGAGAGTATGACTTTCTGGGCATTGCTGAGGTATTAACTGATTTGGTGCCTGCTCAGGAGCTA
CTGATAGATTTAAAACGTACAGCCCAGCAATGCCTTGGCTTAAAGCAACGCTTAATAGAGCGTGGTGTGCCACTGCGCAT
TATCGACATGCCAGCAATTGGCTTTGCTTACCTCGAAGACAAACTAACGCGTTGGGGATTAGCATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16288.59 Da        Isoelectric Point: 10.9167

>AT21832 WP_011787707.1 NC_008750:337047-337493 [Shewanella sp. W3-18-1]
MSDKQTTTETAKDTIARLRANRQQRSDIAIEASQHRQPVNIGDAPIKPTPKRASKQSGGVNTVERKNAINAITQRLLRSE
LSQGQALKALRVEVLGLTQDEYANLVKVSRKTLSDVENDRGSFKTDILDRLFKPFGLKVGIVPISVGP

Download         Length: 447 bp

>AT21832 NC_008750:337047-337493 [Shewanella sp. W3-18-1]
ATGAGTGATAAACAAACGACTACTGAAACGGCTAAAGATACCATCGCCCGTCTTAGAGCTAATCGTCAGCAACGGAGTGA
TATTGCGATTGAGGCGTCACAGCATCGGCAACCCGTAAATATTGGAGATGCTCCAATAAAGCCAACCCCTAAACGCGCCT
CTAAGCAATCAGGCGGTGTTAATACGGTAGAACGCAAGAATGCGATTAACGCTATCACACAACGGCTCTTACGCAGTGAG
CTAAGCCAAGGGCAAGCTCTGAAAGCTCTGCGAGTTGAGGTGCTAGGACTCACGCAAGATGAGTATGCAAACTTGGTTAA
AGTATCGCGCAAGACCCTCTCGGACGTTGAGAACGACCGTGGTAGTTTTAAGACCGATATTCTCGACCGACTATTTAAGC
CTTTTGGTCTTAAGGTCGGGATTGTGCCTATCTCTGTTGGGCCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N3J0D2

Antitoxin

Source ID Structure

References