218319

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3998554..3999070 Replicon chromosome
Accession NZ_CP084216
Organism Salmonella sp. JXY0409-18

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LDB27_RS19460 Protein ID WP_000220578.1
Coordinates 3998554..3998838 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LDB27_RS19465 Protein ID WP_000212724.1
Coordinates 3998828..3999070 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB27_RS19445 (3993670) 3993670..3995322 + 1653 WP_000155039.1 alpha,alpha-phosphotrehalase -
LDB27_RS19450 (3995731) 3995731..3997869 + 2139 WP_000187827.1 anaerobic ribonucleoside-triphosphate reductase -
LDB27_RS19455 (3998086) 3998086..3998550 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LDB27_RS19460 (3998554) 3998554..3998838 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDB27_RS19465 (3998828) 3998828..3999070 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LDB27_RS19470 (3999148) 3999148..4001061 - 1914 WP_001212145.1 BglG family transcription antiterminator -
LDB27_RS19475 (4001078) 4001078..4001818 - 741 WP_000779262.1 KDGP aldolase family protein -
LDB27_RS19480 (4001815) 4001815..4002933 - 1119 WP_001139165.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LDB27_RS19485 (4002917) 4002917..4004050 - 1134 WP_000459952.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T218319 WP_000220578.1 NZ_CP084216:c3998838-3998554 [Salmonella sp. JXY0409-18]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T218319 NZ_CP115831:c4635647-4635114 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGGCAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAAAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT218319 WP_000212724.1 NZ_CP084216:c3999070-3998828 [Salmonella sp. JXY0409-18]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT218319 NZ_CP115831:c4635924-4635658 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References