218318

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3957926..3958476 Replicon chromosome
Accession NZ_CP084216
Organism Salmonella sp. JXY0409-18

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LDB27_RS19245 Protein ID WP_001199743.1
Coordinates 3957926..3958234 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3V9PUN9
Locus tag LDB27_RS19250 Protein ID WP_000016243.1
Coordinates 3958237..3958476 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB27_RS19235 (3953326) 3953326..3956841 - 3516 WP_000342548.1 AAA domain-containing protein -
LDB27_RS19240 (3957203) 3957203..3957504 - 302 Protein_3761 Arm DNA-binding domain-containing protein -
LDB27_RS19245 (3957926) 3957926..3958234 - 309 WP_001199743.1 CcdB family protein Toxin
LDB27_RS19250 (3958237) 3958237..3958476 - 240 WP_000016243.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LDB27_RS19255 (3958585) 3958585..3958809 - 225 WP_031233173.1 ribbon-helix-helix protein, CopG family -
LDB27_RS19270 (3959594) 3959594..3960613 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
LDB27_RS19275 (3960641) 3960641..3961171 - 531 WP_000896756.1 gluconokinase -
LDB27_RS19280 (3961388) 3961388..3962419 + 1032 WP_000453358.1 L-idonate 5-dehydrogenase -
LDB27_RS19285 (3962444) 3962444..3963208 + 765 WP_000998688.1 gluconate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T218318 WP_001199743.1 NZ_CP084216:c3958234-3957926 [Salmonella sp. JXY0409-18]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T218318 NZ_CP115831:4011518-4011736 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATTCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8679.83 Da        Isoelectric Point: 6.4633

>AT218318 WP_000016243.1 NZ_CP084216:c3958476-3958237 [Salmonella sp. JXY0409-18]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRIADEHGLLSDDYRTF

Download         Length: 240 bp

>AT218318 NZ_CP115831:4011117-4011491 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V9PUN9

References