218317

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3340786..3341406 Replicon chromosome
Accession NZ_CP084216
Organism Salmonella sp. JXY0409-18

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LDB27_RS16385 Protein ID WP_001280991.1
Coordinates 3341188..3341406 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LDB27_RS16380 Protein ID WP_000344807.1
Coordinates 3340786..3341160 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB27_RS16370 (3335925) 3335925..3337118 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LDB27_RS16375 (3337141) 3337141..3340290 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LDB27_RS16380 (3340786) 3340786..3341160 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LDB27_RS16385 (3341188) 3341188..3341406 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LDB27_RS16390 (3341585) 3341585..3342136 + 552 WP_001278791.1 maltose O-acetyltransferase -
LDB27_RS16395 (3342254) 3342254..3342724 + 471 WP_000136183.1 YlaC family protein -
LDB27_RS16400 (3342780) 3342780..3342920 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LDB27_RS16405 (3342926) 3342926..3343186 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LDB27_RS16410 (3343411) 3343411..3344961 + 1551 WP_000213134.1 EAL domain-containing protein -
LDB27_RS16420 (3345192) 3345192..3345581 + 390 WP_000961285.1 MGMT family protein -
LDB27_RS16425 (3345614) 3345614..3346183 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T218317 WP_001280991.1 NZ_CP084216:3341188-3341406 [Salmonella sp. JXY0409-18]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T218317 NZ_CP115831:c3881873-3881556 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAAGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT218317 WP_000344807.1 NZ_CP084216:3340786-3341160 [Salmonella sp. JXY0409-18]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT218317 NZ_CP115831:c3881563-3881276 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References