218316

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2299157..2299679 Replicon chromosome
Accession NZ_CP084216
Organism Salmonella sp. JXY0409-18

Toxin (Protein)


Gene name stbE Uniprot ID A0A5J1ICX1
Locus tag LDB27_RS11045 Protein ID WP_000221344.1
Coordinates 2299395..2299679 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LDB27_RS11040 Protein ID WP_000885424.1
Coordinates 2299157..2299405 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB27_RS11010 (2294326) 2294326..2294541 + 216 WP_001530185.1 hypothetical protein -
LDB27_RS11015 (2294975) 2294975..2295898 + 924 WP_023230780.1 hypothetical protein -
LDB27_RS11020 (2296313) 2296313..2296888 + 576 Protein_2154 helix-turn-helix domain-containing protein -
LDB27_RS11025 (2296959) 2296959..2297909 - 951 WP_000941990.1 toll/interleukin-1 receptor domain-containing protein -
LDB27_RS11030 (2298073) 2298073..2298405 - 333 WP_000253166.1 DUF1493 family protein -
LDB27_RS11035 (2298399) 2298399..2298857 - 459 WP_000381836.1 hypothetical protein -
LDB27_RS11040 (2299157) 2299157..2299405 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LDB27_RS11045 (2299395) 2299395..2299679 + 285 WP_000221344.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDB27_RS11050 (2299798) 2299798..2300079 + 282 Protein_2160 RidA family protein -
LDB27_RS11055 (2300131) 2300131..2301210 - 1080 WP_000954705.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LDB27_RS11060 (2301403) 2301403..2301891 - 489 WP_001293633.1 MarR family winged helix-turn-helix transcriptional regulator -
LDB27_RS11065 (2301936) 2301936..2303444 + 1509 WP_000199421.1 FAD-dependent oxidoreductase -
LDB27_RS11070 (2303434) 2303434..2304675 + 1242 WP_001095723.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2293414..2306301 12887


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11015.73 Da        Isoelectric Point: 10.5388

>T218316 WP_000221344.1 NZ_CP084216:2299395-2299679 [Salmonella sp. JXY0409-18]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS

Download         Length: 285 bp

>T218316 NZ_CP115831:c2688278-2686956 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTATCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT218316 WP_000885424.1 NZ_CP084216:2299157-2299405 [Salmonella sp. JXY0409-18]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT218316 NZ_CP115831:c2688544-2688278 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J1ICX1

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References