Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 308340..308890 Replicon chromosome
Accession NC_008750
Organism Shewanella sp. W3-18-1

Toxin (Protein)


Gene name parE Uniprot ID A0A6N3J068
Locus tag SPUTW3181_RS01475 Protein ID WP_011787679.1
Coordinates 308340..308639 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6N3J071
Locus tag SPUTW3181_RS01480 Protein ID WP_011787680.1
Coordinates 308648..308890 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPUTW3181_RS01455 303702..304268 - 567 WP_011787675.1 XRE family transcriptional regulator -
SPUTW3181_RS01460 304432..305619 + 1188 WP_011787676.1 benzoate/H(+) symporter BenE family transporter -
SPUTW3181_RS01465 305671..306147 - 477 WP_011787677.1 GNAT family N-acetyltransferase -
SPUTW3181_RS01470 306599..307762 - 1164 WP_011787678.1 HNH endonuclease -
SPUTW3181_RS01475 308340..308639 - 300 WP_011787679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SPUTW3181_RS01480 308648..308890 - 243 WP_011787680.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SPUTW3181_RS01485 309169..309912 - 744 WP_011787681.1 hypothetical protein -
SPUTW3181_RS01490 309944..311203 - 1260 WP_011787682.1 beta-ketoacyl-ACP synthase -
SPUTW3181_RS01495 311204..311929 - 726 WP_011787683.1 3-ketoacyl-ACP reductase FabG2 -
SPUTW3181_RS01500 312042..312575 - 534 WP_011787684.1 hotdog family protein -
SPUTW3181_RS01505 312580..313779 - 1200 WP_041407878.1 beta-ketoacyl-[acyl-carrier-protein] synthase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-66)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11553.37 Da        Isoelectric Point: 9.5972

>T21831 WP_011787679.1 NC_008750:c308639-308340 [Shewanella sp. W3-18-1]
MKNKRYKLSKLAQTHLLKIKDYTLQHFSESQWHKYKESLISGLQMLADNPGLGRSCEDIYPNGFYFPIAKHTAYFTKEDD
FILIVALLGQPQLPQNHLK

Download         Length: 300 bp

>T21831 NC_008750:c308639-308340 [Shewanella sp. W3-18-1]
ATGAAAAATAAACGCTATAAACTGAGTAAGTTAGCTCAAACTCACTTACTAAAGATTAAAGACTACACCCTTCAACACTT
TTCTGAGTCGCAGTGGCACAAATACAAAGAAAGCCTAATATCCGGCTTGCAAATGTTAGCCGATAACCCCGGATTAGGCA
GAAGCTGCGAAGATATTTACCCCAACGGATTCTACTTTCCGATTGCTAAACACACCGCCTACTTCACAAAAGAAGACGAC
TTCATCCTCATCGTTGCCCTGTTAGGCCAGCCACAACTACCACAAAACCACTTGAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8920.14 Da        Isoelectric Point: 5.0621

>AT21831 WP_011787680.1 NC_008750:c308890-308648 [Shewanella sp. W3-18-1]
VQTLTANDAKRNFGELLLNAQREPIKISKNSKDAVVVMSIHDFEQLEAMKADYLKHCFNAAKEDLAKGNIVDGEDFLNAL

Download         Length: 243 bp

>AT21831 NC_008750:c308890-308648 [Shewanella sp. W3-18-1]
GTGCAAACATTAACAGCCAATGACGCCAAACGAAATTTCGGTGAGTTACTGCTAAACGCTCAACGTGAACCTATCAAGAT
CAGCAAAAACAGTAAAGATGCGGTTGTTGTGATGTCTATCCACGACTTCGAACAACTTGAGGCGATGAAAGCGGATTACC
TTAAACACTGCTTCAACGCTGCTAAAGAAGACTTAGCGAAAGGTAATATTGTTGATGGTGAAGATTTTCTTAACGCCCTG
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N3J068

Antitoxin

Source ID Structure
AlphaFold DB A0A6N3J071

References