218307

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 816158..816818 Replicon chromosome
Accession NZ_CP084216
Organism Salmonella sp. JXY0409-18

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LDB27_RS03950 Protein ID WP_000244756.1
Coordinates 816405..816818 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LDB27_RS03945 Protein ID WP_000351186.1
Coordinates 816158..816424 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB27_RS03925 (812087) 812087..813520 - 1434 WP_001230152.1 6-phospho-beta-glucosidase BglA -
LDB27_RS03930 (813678) 813678..813989 + 312 WP_001182972.1 N(4)-acetylcytidine aminohydrolase -
LDB27_RS03935 (814153) 814153..814812 + 660 WP_000250289.1 hemolysin III family protein -
LDB27_RS03940 (814928) 814928..815908 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
LDB27_RS03945 (816158) 816158..816424 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LDB27_RS03950 (816405) 816405..816818 + 414 WP_000244756.1 protein YgfX Toxin
LDB27_RS03955 (816871) 816871..817392 - 522 WP_001055885.1 flavodoxin FldB -
LDB27_RS03960 (817505) 817505..818401 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LDB27_RS03965 (818425) 818425..819138 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LDB27_RS03970 (819144) 819144..820877 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T218307 WP_000244756.1 NZ_CP084216:816405-816818 [Salmonella sp. JXY0409-18]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T218307 NZ_CP115820:4431510-4431854 [Pseudomonas tohonis]
ATGAGCAGAACGATTGAGGTCGCCTACGCGACCACCGCAGAAGAAAGCCTGATTTCGCAGATACACCACCTGACGCCTTT
CCTGGGCGCCGAACAGGCCTACGCCAAGCTCGCAACCCTGATCAAAAGCGCCGAGCGCCATCTGAAGGCCCACCCGCTGG
CCGCCCCCGTCTGCGAGCAAGCTGCCCTCTTGGGCGTCCGCGGGTATCACGAGCTGCACATCGAGGAATTCCGCATCCTC
TATCGATACGACGACGCCGCCAGCCTGGTAATGGTCGCGCTGGTCCTGCGACAGCGTCAGAGCATCGAAGAGCAACTGAT
CAACTACTGCCTGATGCGCGAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT218307 WP_000351186.1 NZ_CP084216:816158-816424 [Salmonella sp. JXY0409-18]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT218307 NZ_CP115820:4431242-4431526 [Pseudomonas tohonis]
ATGAAAGTCCGAACCATCAGCTACCTGAAGCAGCATGCGGCCTCGCTGGACCTGAGCGAGCCCATGGTCATCACCCAGAA
CGGCGTTCCAGCCTACGTGGTGGAGTCCTATGCCGAGCGCCGCCGCCGCGACGAGGCCCTGGCGCTGATCAAGCTGCTGT
CATTCGCGGAGCGGGACAAGGCCGAAGGCCGCCTCATCTCCAGCGATTCCCTTCTGCAGCGCCTTAAACAGCGCAGCCCT
GTCGCCCAAGGACCGGGGGAAAGCGGGGATGAGCAGAACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References