Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 209033..209793 Replicon chromosome
Accession NZ_CP084216
Organism Salmonella sp. JXY0409-18

Toxin (Protein)


Gene name tacT Uniprot ID A0A3V9PR68
Locus tag LDB27_RS00985 Protein ID WP_000533907.1
Coordinates 209308..209793 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LDB27_RS00980 Protein ID WP_000965886.1
Coordinates 209033..209320 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB27_RS00955 (204122) 204122..204424 + 303 WP_000605592.1 YsaB family lipoprotein -
LDB27_RS00960 (204563) 204563..205474 + 912 WP_001168556.1 glycine--tRNA ligase subunit alpha -
LDB27_RS00965 (205484) 205484..207553 + 2070 WP_001291738.1 glycine--tRNA ligase subunit beta -
LDB27_RS00970 (207815) 207815..208246 + 432 Protein_193 IS3 family transposase -
LDB27_RS00975 (208388) 208388..208855 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
LDB27_RS00980 (209033) 209033..209320 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LDB27_RS00985 (209308) 209308..209793 + 486 WP_000533907.1 GNAT family N-acetyltransferase Toxin
LDB27_RS00990 (210164) 210164..210703 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
LDB27_RS00995 (210876) 210876..211088 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LDB27_RS01000 (211376) 211376..211666 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LDB27_RS01005 (212105) 212105..212815 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LDB27_RS01010 (212865) 212865..213839 - 975 WP_000804695.1 glyoxylate/hydroxypyruvate reductase GhrB -
LDB27_RS01015 (214069) 214069..214731 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17715.46 Da        Isoelectric Point: 9.8719

>T218306 WP_000533907.1 NZ_CP084216:209308-209793 [Salmonella sp. JXY0409-18]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALIEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T218306 NZ_CP115820:c3911614-3911243 [Pseudomonas tohonis]
GTGCTGCTCTATCTGCTGTCCGCCGATCCGGCCAAGGCGGATGCCGCCGAAGCATTGCTGGCGAAGAGGCCGACGATCAG
CGTGCAGGTTCTCAATGAGGTGGCCAGCGTCTGCTCCCGCAAGTTGAGGATGAGCTGGGATGAGATCGGCCGTTTCCTTG
AACTGGTGCAAGGCTTCTGTCGCGTCGTACCGGTGACGCTGGAGATCCACCGGCAGGCGCGTGAGCTGGCTGAGCGCTAC
AGGCTGTCTTTCTACGATGCCTGTATCGCCGCCGCTGCGCTTGTCGCGGGCTGCTCGACCCTCCACAGCGAAGACATGCA
CTCGGGGTTGCTCCTCGATGGGCGTTTGCGGGTGCTGAATCCGTTCGGCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT218306 WP_000965886.1 NZ_CP084216:209033-209320 [Salmonella sp. JXY0409-18]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT218306 NZ_CP115820:c3911876-3911640 [Pseudomonas tohonis]
ATGCAGGTCGCGAAGTGGGGAAACAGCCTGGCGGTGCGTATACCGGCGAGCGTGGTCGAGGCGCTGGAACTGAAGGAGGG
TGACGATATCGAGATACTGATCGAGGGTGATCGCACCTTCGCCATCAGCAAGAAACCTGACGATGAGGGGCGGCTTGCGC
GGCTACGGGCGTTTCGCGGCAAGTTGCCGGCGGATTTCCGTTTCAACCGCGATGAGGACGCTGGCCGTGAGGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9PR68

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References