Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/upstrm_HI1419-dnstrm_HI1420 |
Location | 5523579..5524174 | Replicon | chromosome |
Accession | NZ_CP084212 | ||
Organism | Pseudomonas amygdali strain 35-1 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A3M3ZKH5 |
Locus tag | LCH33_RS24550 | Protein ID | WP_005746690.1 |
Coordinates | 5523579..5523881 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0P9S822 |
Locus tag | LCH33_RS24555 | Protein ID | WP_005746689.1 |
Coordinates | 5523884..5524174 (+) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LCH33_RS24530 (LCH33_004882) | 5518912..5520189 | - | 1278 | WP_057404492.1 | precorrin-3B synthase | - |
LCH33_RS24535 (LCH33_004883) | 5520378..5521580 | + | 1203 | WP_016982357.1 | bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase | - |
LCH33_RS24540 (LCH33_004884) | 5521580..5522692 | + | 1113 | WP_054076830.1 | cobalt-precorrin-5B (C(1))-methyltransferase | - |
LCH33_RS24545 (LCH33_004885) | 5522689..5523429 | + | 741 | WP_057404491.1 | cobalt-precorrin-6A reductase | - |
LCH33_RS24550 (LCH33_004886) | 5523579..5523881 | + | 303 | WP_005746690.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
LCH33_RS24555 (LCH33_004887) | 5523884..5524174 | + | 291 | WP_005746689.1 | putative addiction module antidote protein | Antitoxin |
LCH33_RS24560 (LCH33_004888) | 5524245..5524706 | + | 462 | WP_002555389.1 | copper chaperone PCu(A)C | - |
LCH33_RS24565 (LCH33_004889) | 5524720..5525154 | + | 435 | WP_016982355.1 | DUF2946 domain-containing protein | - |
LCH33_RS24570 (LCH33_004890) | 5525239..5526612 | + | 1374 | WP_005746685.1 | PepSY domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11477.21 Da Isoelectric Point: 10.6008
>T218301 WP_005746690.1 NZ_CP084212:5523579-5523881 [Pseudomonas amygdali]
MNRFEQTPAFAEWLRSLKDSIGRARILARIRAAELGNFGDCDALGQGVRELRIHHGPGYRVYFARRTGVVYLLLIAGDKS
SQKRDIKFARQLARELCERE
MNRFEQTPAFAEWLRSLKDSIGRARILARIRAAELGNFGDCDALGQGVRELRIHHGPGYRVYFARRTGVVYLLLIAGDKS
SQKRDIKFARQLARELCERE
Download Length: 303 bp
>T218301 NZ_CP115818:3648-3986 [Pseudomonas mendocina]
ATGACAACATTCGACGTACGCTTCACCGATTCCGCTTCTCAAAGCATCGAAGACCAGGTTCACCATCTGGCCGTTTACCA
GGGCACCGAAGCTGCCCTCGCGAGAATTGACTCGCTGGTAGATGTCATCACGGACAAACTCAAGTCCACCCCAATGGGAT
ACCCAGTCAGCCAGCAGGCGAGTGAGTTGGGGATCATCCATTACCGCGAACTCAATACGGACGGCTATCGAATCCTCTAT
GAGATTTTCGATACCGACATCGCGGTCGAGCTGGTTATAAGGCAGAAGCAGAGCGTCGAGCAGGCCCTGATCCGCTACTG
TTTGCTGAATCCGTTGTAG
ATGACAACATTCGACGTACGCTTCACCGATTCCGCTTCTCAAAGCATCGAAGACCAGGTTCACCATCTGGCCGTTTACCA
GGGCACCGAAGCTGCCCTCGCGAGAATTGACTCGCTGGTAGATGTCATCACGGACAAACTCAAGTCCACCCCAATGGGAT
ACCCAGTCAGCCAGCAGGCGAGTGAGTTGGGGATCATCCATTACCGCGAACTCAATACGGACGGCTATCGAATCCTCTAT
GAGATTTTCGATACCGACATCGCGGTCGAGCTGGTTATAAGGCAGAAGCAGAGCGTCGAGCAGGCCCTGATCCGCTACTG
TTTGCTGAATCCGTTGTAG
Antitoxin
Download Length: 97 a.a. Molecular weight: 10500.87 Da Isoelectric Point: 4.5720
>AT218301 WP_005746689.1 NZ_CP084212:5523884-5524174 [Pseudomonas amygdali]
MNNETTPFDTVDYLKTPEDMANYLDACLEEDSGDGLLVRAALNDIARAYGMTQIARDTGLGRESLYKALGANGNPEFTTI
MKVVRAMGIKLHASTR
MNNETTPFDTVDYLKTPEDMANYLDACLEEDSGDGLLVRAALNDIARAYGMTQIARDTGLGRESLYKALGANGNPEFTTI
MKVVRAMGIKLHASTR
Download Length: 291 bp
>AT218301 NZ_CP115818:3387-3635 [Pseudomonas mendocina]
ATGAGGGTTGAAACGATTAGCTATTTGAAACGACACGCTGCCGATCTGGATCTCGATGAGCCCATGGTCGTCACGCAGAA
CGGTGTACCAGCCTATGTCGTGGAGTCTTACGCAGACCGTAAGCGCCGCGATGAAGCCATCGCTCTGGTGAAACTGCTCG
CAATTGGTTCTCGCGAGTACGCCCAAGGTAAGCATTGTTCTGCTGACGAACTGAAGGCCCGCCTGGCCAGGAGGTTTGCC
CAACACTAA
ATGAGGGTTGAAACGATTAGCTATTTGAAACGACACGCTGCCGATCTGGATCTCGATGAGCCCATGGTCGTCACGCAGAA
CGGTGTACCAGCCTATGTCGTGGAGTCTTACGCAGACCGTAAGCGCCGCGATGAAGCCATCGCTCTGGTGAAACTGCTCG
CAATTGGTTCTCGCGAGTACGCCCAAGGTAAGCATTGTTCTGCTGACGAACTGAAGGCCCGCCTGGCCAGGAGGTTTGCC
CAACACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3M3ZKH5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0P9S822 |