Detailed information of TA system TA021830

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 3742656..3743681
• Replicon: chromosome
• Accession: NC_008740
• Organism: Marinobacter aquaeolei VT8

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: MAQU_RS17245
• Protein ID: WP_011786796.1
• Coordinates: 3742656..3743222 (-)
• Length: 189 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A1U637
• Locus tag: MAQU_RS17250
• Protein ID: WP_011786797.1
• Coordinates: 3743229..3743681 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAQU_RS17225	3738781..3739395	+	615	WP_011786793.1	Fic family protein	-
MAQU_RS23095	3739412..3739576	-	165	WP_198324790.1	hypothetical protein	-
MAQU_RS17235	3739825..3741282	+	1458	WP_011786794.1	restriction endonuclease subunit S	-
MAQU_RS17240	3741282..3742337	+	1056	WP_011786795.1	restriction endonuclease	-
MAQU_RS17245	3742656..3743222	-	567	WP_011786796.1	PIN domain-containing protein	Toxin
MAQU_RS17250	3743229..3743681	-	453	WP_011786797.1	helix-turn-helix domain-containing protein	Antitoxin
MAQU_RS17255	3743900..3747058	+	3159	WP_011786798.1	type I restriction endonuclease subunit R	-
MAQU_RS17260	3747206..3748360	-	1155	WP_011786799.1	trypsin-like peptidase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-112)

Antitoxin

• Helix-turn-helix domain, group 17 (81-127)

Sequences

Toxin

Protein

• Length: 189 a.a.
• Molecular weight: 21521.77 Da
• Isoelectric Point: 6.4884

>T21830 WP_011786796.1 NC_008740:c3743222-3742656 [Marinobacter hydrocarbonoclasticus VT8]
MSKFTVVYDACGLYPAPLRDALMRLALTDLFKAHWTDHIHDEWINALLRAKKHSPDSLLRARELMDRHVRDAKVYGYEPL
IEGLSLPDPDDRHVLAAAIRCNASAIVTFNLKDFPEASLHQYDIEFIHPDDFILYQIDMAPTVCCRAFQAQRSALKNPPL
SVDTFLATLQKQQLPQTVSKLREFADFL

Nucleotide

• Length: 567 bp

>T21830 NC_008740:c3743222-3742656 [Marinobacter hydrocarbonoclasticus VT8]
ATGAGCAAATTCACCGTCGTTTACGATGCCTGCGGACTCTATCCCGCCCCCTTGCGGGATGCGCTGATGCGGCTGGCATT
AACGGACTTGTTCAAAGCGCATTGGACGGACCACATACACGACGAGTGGATCAACGCGCTGTTGAGGGCGAAGAAACATT
CGCCGGATAGCTTGTTGCGGGCGAGGGAACTGATGGATCGGCATGTGCGCGATGCCAAAGTGTACGGTTACGAGCCGCTG
ATCGAAGGGCTAAGCCTGCCGGACCCTGACGATCGCCACGTGCTGGCCGCTGCCATCCGTTGTAACGCCAGCGCCATTGT
TACCTTCAACCTGAAGGATTTTCCCGAAGCATCGCTTCACCAGTACGATATCGAATTTATCCACCCGGACGACTTTATTC
TCTACCAGATCGACATGGCGCCAACTGTGTGTTGCCGCGCTTTTCAGGCCCAGCGGTCGGCGCTGAAGAATCCGCCACTC
AGTGTCGATACCTTTCTGGCAACGCTGCAAAAGCAGCAGTTACCCCAAACGGTCTCGAAGCTTCGGGAGTTTGCGGATTT
CCTCTAG

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16653.90 Da
• Isoelectric Point: 5.5879

>AT21830 WP_011786797.1 NC_008740:c3743681-3743229 [Marinobacter hydrocarbonoclasticus VT8]
MSAQKIVHLPTAAEVEQAKLSSRTLSKYADVDRVQLSLRGSNGETDELVLPGHVLQILLDVLAEVSQGNAISLIPYHQEI
STQDAANLLNVSRPFLVRLLESGDIPFRKVGAHRRVKLQDVLSYKEQIDRQRHAALDELAELSQDEGMGY

Nucleotide

• Length: 453 bp

>AT21830 NC_008740:c3743681-3743229 [Marinobacter hydrocarbonoclasticus VT8]
ATGTCTGCTCAGAAAATAGTACATTTGCCAACGGCTGCAGAGGTGGAACAGGCCAAGCTGTCCAGTCGCACCTTGTCCAA
ATATGCCGATGTGGATCGTGTACAGCTCTCGCTGCGTGGCAGCAACGGCGAGACTGACGAACTGGTACTGCCCGGGCATG
TGCTACAAATTCTGCTGGATGTTCTGGCGGAAGTGTCTCAGGGCAATGCCATCAGCCTGATTCCCTATCACCAAGAAATC
AGCACACAGGATGCGGCGAACCTCCTGAACGTCAGTCGCCCCTTCCTCGTGAGGCTACTGGAGTCTGGTGATATACCCTT
CCGGAAGGTGGGAGCCCATCGGCGGGTTAAGCTGCAGGATGTCCTGAGCTACAAGGAACAGATAGATCGCCAACGGCACG
CCGCACTGGATGAATTGGCCGAACTGTCACAGGACGAGGGAATGGGGTACTGA

Structures

Antitoxin

• AlphaFold DB: A1U637