Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4034634..4035229 Replicon chromosome
Accession NZ_CP084209
Organism Escherichia coli strain EC2648-R2

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag LDB16_RS19685 Protein ID WP_000239577.1
Coordinates 4034634..4034984 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag LDB16_RS19690 Protein ID WP_001223208.1
Coordinates 4034978..4035229 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB16_RS19665 (4030080) 4030080..4031102 - 1023 WP_001313531.1 ABC transporter permease -
LDB16_RS19670 (4031116) 4031116..4032618 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
LDB16_RS19675 (4032758) 4032758..4033714 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LDB16_RS19680 (4034024) 4034024..4034554 + 531 WP_000055075.1 inorganic diphosphatase -
LDB16_RS19685 (4034634) 4034634..4034984 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
LDB16_RS19690 (4034978) 4034978..4035229 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LDB16_RS19695 (4035441) 4035441..4035782 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LDB16_RS19700 (4035785) 4035785..4039564 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T218296 WP_000239577.1 NZ_CP084209:c4034984-4034634 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T218296 NZ_CP115784:c181131-180841 [Paracoccus aerodenitrificans]
ATGACGTCATCCTATTTGCTTACGCCACTGGCGGAAACGGATCTCGAAGAGATCTGGCTTTACACAGCACGTCGCTGGTC
GCCAGAGCAAGCCGAGATTTACACCAATGACATCATTGATGCATGCGAGGATCTCGTAAGCGGAAGGAAGTCAGGGCGCC
CGGTTGCCATTCGTGACGGATATTTCAAAACAATGGCAGGCCGACACATCATCTACTTCCAGCGCAGGGCAGAAACTCTG
CTAGTCGTCCGCATTCTTCACCAGAGAATGGACATCAAGAGTCACCTATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT218296 WP_001223208.1 NZ_CP084209:c4035229-4034978 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT218296 NZ_CP115784:c181376-181131 [Paracoccus aerodenitrificans]
ATGGCAAAGAATACCTCAATGTCCCTTGGCGACCATTTCGCGGGGTTTATCGAATCGCAGGTCAGCAACGGTCGTTACGG
GTCTGCAAGCGAAGTCGTGCGCGCCGGGTTGCGGCTCCTCGAAGAGCAGGAGGCCAAGGTGCAGGCCTTGAAAGACGCCC
TGATTGCTGGAGAAAATTCCGGCGTTCCGCGCCCCCTTGATCGGGATGCCTTTCAGGCCCGGATGCGTCAAAAGCACCAA
TCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References