Detailed information of TA system TA218295

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3949623..3950437
• Replicon: chromosome
• Accession: NZ_CP084209
• Organism: Escherichia coli strain EC2648-R2

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: LDB16_RS19250
• Protein ID: WP_001054376.1
• Coordinates: 3949623..3949880 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: LDB16_RS19255
• Protein ID: WP_001309181.1
• Coordinates: 3949892..3950437 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	3938633..3958661	20028

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T218295 WP_001054376.1 NZ_CP084209:3949623-3949880 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T218295 NZ_CP115782:15360-15641 [Paracoccus aerodenitrificans]
ATGATCCAAAGTACCAAGGGAAAGCTGATCCAGGACGTTCTGGCGAACAAGGCCAGCAAAGGCTTTCCCGCCGGTATCAT
GAAGGTTGCACGCCGCAAGCTGACCATGATCGACGCGGCGAGCAAGCTTGAGGATTTGCGGATGCCGCCTGCCAACAGGC
TTGAGGCGCTTCAAGGCGACCGCAAAGAGCAATACTCGATCCGGGTGAACGACCAATGGCGCTTTTGTTTCGTCTGGACC
GAAAGCGGCCCTGCTGATGTTGAATTTACGGACTACCACTGA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT218295 WP_001309181.1 NZ_CP084209:3949892-3950437 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT218295 NZ_CP115782:15654-15944 [Paracoccus aerodenitrificans]
ATGGGACTGATGACCAACCCCTGCCACCCCGGCGAGATCCTCAAGCATGAATTTCTTGAGCCGCTCGGGGTTTCGGCGAT
TGGCCTGGCAAAAGCGATTGGCGTGCCACGCACGCGGGTTGAGCGACTGGTTAAGGAACAAACGGGGGTAACCCCTGACA
CGGCCCTGCGCCTGTCGAAAGCTCTTGGGACGACCCCTGAATTTTGGATCAATATGCAGGCGAATTTTGACATGGCCTCT
GCCCGTAAGAGCGTCGATGTGTCAGGCATTGAGCCGCTCATAGCGGCCTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8