218289

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3398525..3399143 Replicon chromosome
Accession NZ_CP084209
Organism Escherichia coli strain EC2648-R2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LDB16_RS16545 Protein ID WP_001291435.1
Coordinates 3398925..3399143 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LDB16_RS16540 Protein ID WP_000344800.1
Coordinates 3398525..3398899 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB16_RS16530 (3393614) 3393614..3394807 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LDB16_RS16535 (3394830) 3394830..3397979 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LDB16_RS16540 (3398525) 3398525..3398899 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LDB16_RS16545 (3398925) 3398925..3399143 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LDB16_RS16550 (3399315) 3399315..3399866 + 552 WP_000102564.1 maltose O-acetyltransferase -
LDB16_RS16555 (3399982) 3399982..3400452 + 471 WP_001716237.1 YlaC family protein -
LDB16_RS16560 (3400616) 3400616..3402166 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LDB16_RS16565 (3402208) 3402208..3402561 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LDB16_RS16575 (3402940) 3402940..3403251 + 312 WP_000409911.1 MGMT family protein -
LDB16_RS16580 (3403282) 3403282..3403854 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T218289 WP_001291435.1 NZ_CP084209:3398925-3399143 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T218289 NZ_CP115776:c184520-184272 [Paracoccus albus]
ATGTGGAGTCTGCAGGACGCGAAGAACAAGTTTTCCGCTGTGGTGGATGCGGCGCTTGCGGGTGAGCCGCAAGAAGTCAC
GCGCCGGGGTAAGCCGGCTGTGGTCGTGCTTTCGGCATCCGAATATGCGCGGATATTGGCAGAGGCGCAGTCGAATCGTG
GCAGTTTCGCCAAGCATCTTCTGACCCAGCCACGCGGCGAGGTAGAGGCGGAACGGGCAGAGGCCCGGCCGCGCGACGTA
GCTTTCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT218289 WP_000344800.1 NZ_CP084209:3398525-3398899 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT218289 NZ_CP115776:c184272-183868 [Paracoccus albus]
ATGCTGATCCTTGACACGAATGTTATATCGGCGCTGCGCAGGCCAGAACGCGCGCCAGAGGTCGCGGCGTGGTTGAAGCG
GCAGGATGACAATGTGCTGTATCTGTCTGTCGTAACCCTCGGCGAGATTGAGCGCGGCATCGCGCGACAGGAACAGCAGG
ACCCGGCTTTTGCGCGCGATCTGCGCAACTGGCTGGGTCGGACGGTGCAGTTGTTCGGTGATCGCCTGCTGCCATTCGAT
GCGCAATCCGCGCGGATCTGGGGACAGTTGTCGGCGCGGTTGGGGCATGCGGGTGCCGATCTGCTGATTGCTGCAACAGC
ACTGCATCACGATGCGGTTGTCGTTACGCGCAATGTCTCGGACTTTGAGCCGACGGGTTGCCGGATCGAAAACCCCTTTG
CGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References