Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA(toxin) |
| Location | 2995828..2996417 | Replicon | chromosome |
| Accession | NC_008740 | ||
| Organism | Marinobacter aquaeolei VT8 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | U7NWJ6 |
| Locus tag | MAQU_RS13660 | Protein ID | WP_011786112.1 |
| Coordinates | 2995828..2996079 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | U7NUU7 |
| Locus tag | MAQU_RS13665 | Protein ID | WP_011786113.1 |
| Coordinates | 2996076..2996417 (+) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MAQU_RS13625 | 2992096..2992851 | + | 756 | WP_011786106.1 | IS21-like element ISSpu5 family helper ATPase IstB | - |
| MAQU_RS13630 | 2992955..2993401 | - | 447 | Protein_2685 | hypothetical protein | - |
| MAQU_RS13635 | 2993663..2993920 | - | 258 | Protein_2686 | type VI secretion system PAAR protein | - |
| MAQU_RS13640 | 2993947..2994246 | - | 300 | WP_011786108.1 | CcdB family protein | - |
| MAQU_RS13645 | 2994246..2994491 | - | 246 | WP_011786109.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| MAQU_RS13650 | 2994585..2995190 | - | 606 | WP_011786110.1 | alpha-ketoglutarate-dependent dioxygenase AlkB | - |
| MAQU_RS13655 | 2995292..2995552 | + | 261 | WP_011786111.1 | hypothetical protein | - |
| MAQU_RS13660 | 2995828..2996079 | + | 252 | WP_011786112.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MAQU_RS13665 | 2996076..2996417 | + | 342 | WP_011786113.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MAQU_RS13670 | 2996546..2996821 | - | 276 | Protein_2693 | BrnA antitoxin family protein | - |
| MAQU_RS13675 | 2996846..2997169 | - | 324 | WP_011786115.1 | putative addiction module antidote protein | - |
| MAQU_RS13680 | 2997166..2997465 | - | 300 | WP_011786116.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MAQU_RS13685 | 2997575..2997877 | - | 303 | WP_011786117.1 | XRE family transcriptional regulator | - |
| MAQU_RS22505 | 2998195..2998368 | + | 174 | WP_011786119.1 | hypothetical protein | - |
| MAQU_RS13690 | 2998643..2998945 | - | 303 | WP_011786120.1 | hypothetical protein | - |
| MAQU_RS13695 | 2998947..2999219 | - | 273 | WP_011786121.1 | DUF4258 domain-containing protein | - |
| MAQU_RS13700 | 2999401..2999724 | - | 324 | WP_011786122.1 | helix-turn-helix domain-containing protein | - |
| MAQU_RS13705 | 2999711..2999965 | - | 255 | WP_049756940.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MAQU_RS13710 | 3000152..3001114 | + | 963 | WP_041656980.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2983984..2997465 | 13481 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9415.88 Da Isoelectric Point: 10.7592
>T21826 WP_011786112.1 NC_008740:2995828-2996079 [Marinobacter hydrocarbonoclasticus VT8]
MSKHGKLLTKLLNKHSTFTWQELTTLLKSLGYRQIEGHGSRVKFDNGDPQALINLHKPHPGNELKAYARRQIIENLKSGG
LIQ
MSKHGKLLTKLLNKHSTFTWQELTTLLKSLGYRQIEGHGSRVKFDNGDPQALINLHKPHPGNELKAYARRQIIENLKSGG
LIQ
Download Length: 252 bp
>T21826 NC_008740:2995828-2996079 [Marinobacter hydrocarbonoclasticus VT8]
ATGTCAAAGCACGGAAAGCTACTGACAAAATTGCTGAACAAGCATTCAACATTTACCTGGCAGGAACTGACAACGCTTCT
AAAAAGTCTCGGCTATCGCCAGATAGAAGGTCACGGTAGCCGCGTTAAGTTCGACAATGGAGACCCGCAAGCTCTGATTA
ACCTTCACAAACCGCATCCCGGCAATGAGCTAAAAGCTTATGCAAGGCGCCAGATAATCGAGAACCTTAAATCCGGAGGG
CTAATTCAATGA
ATGTCAAAGCACGGAAAGCTACTGACAAAATTGCTGAACAAGCATTCAACATTTACCTGGCAGGAACTGACAACGCTTCT
AAAAAGTCTCGGCTATCGCCAGATAGAAGGTCACGGTAGCCGCGTTAAGTTCGACAATGGAGACCCGCAAGCTCTGATTA
ACCTTCACAAACCGCATCCCGGCAATGAGCTAAAAGCTTATGCAAGGCGCCAGATAATCGAGAACCTTAAATCCGGAGGG
CTAATTCAATGA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12769.33 Da Isoelectric Point: 5.5737
>AT21826 WP_011786113.1 NC_008740:2996076-2996417 [Marinobacter hydrocarbonoclasticus VT8]
MSNMLKYRGYYGSIEVSTEDNCLFGKLQFIRALVNYEGETVSELEKAFQEAVDDYLNTCANQNIKPEIPCKGSFNVRVGH
DLHLAASVAARRQSISLNDLTRNALSEYLEHHP
MSNMLKYRGYYGSIEVSTEDNCLFGKLQFIRALVNYEGETVSELEKAFQEAVDDYLNTCANQNIKPEIPCKGSFNVRVGH
DLHLAASVAARRQSISLNDLTRNALSEYLEHHP
Download Length: 342 bp
>AT21826 NC_008740:2996076-2996417 [Marinobacter hydrocarbonoclasticus VT8]
ATGAGCAACATGCTGAAATATCGAGGCTACTACGGCTCTATTGAAGTGAGCACGGAAGATAATTGCCTGTTTGGAAAACT
GCAGTTCATTCGGGCACTGGTTAATTATGAAGGAGAAACAGTCTCAGAGCTTGAGAAAGCATTCCAGGAAGCGGTGGACG
ACTATCTGAACACTTGCGCAAACCAGAACATAAAACCCGAAATACCCTGCAAGGGTTCGTTTAATGTGCGAGTTGGCCAC
GATTTACACTTGGCGGCTAGCGTCGCTGCCCGCCGCCAAAGCATCTCTCTGAACGACCTTACACGCAACGCGCTCAGCGA
GTATCTGGAGCACCACCCTTGA
ATGAGCAACATGCTGAAATATCGAGGCTACTACGGCTCTATTGAAGTGAGCACGGAAGATAATTGCCTGTTTGGAAAACT
GCAGTTCATTCGGGCACTGGTTAATTATGAAGGAGAAACAGTCTCAGAGCTTGAGAAAGCATTCCAGGAAGCGGTGGACG
ACTATCTGAACACTTGCGCAAACCAGAACATAAAACCCGAAATACCCTGCAAGGGTTCGTTTAATGTGCGAGTTGGCCAC
GATTTACACTTGGCGGCTAGCGTCGCTGCCCGCCGCCAAAGCATCTCTCTGAACGACCTTACACGCAACGCGCTCAGCGA
GTATCTGGAGCACCACCCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|