Detailed information of TA system TA021823

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 3107782..3108317
• Replicon: chromosome
• Accession: NC_008726
• Organism: Mycobacterium vanbaalenii PYR-1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A1T986
• Locus tag: MVAN_RS14730
• Protein ID: WP_011780141.1
• Coordinates: 3107782..3108114 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: MVAN_RS14735
• Protein ID: WP_041306533.1
• Coordinates: 3108111..3108317 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MVAN_RS14705	3103458..3104009	+	552	WP_011780139.1	YaeQ family protein	-
MVAN_RS14710	3104028..3104291	-	264	WP_011780140.1	hypothetical protein	-
MVAN_RS14715	3104442..3105257	-	816	WP_011777844.1	ExeA family protein	-
MVAN_RS14720	3105254..3106753	-	1500	WP_011777855.1	DDE-type integrase/transposase/recombinase	-
MVAN_RS14725	3106865..3107464	-	600	WP_011777841.1	hypothetical protein	-
MVAN_RS14730	3107782..3108114	-	333	WP_011780141.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MVAN_RS14735	3108111..3108317	-	207	WP_041306533.1	DUF3018 family protein	Antitoxin
MVAN_RS14740	3108637..3109287	-	651	WP_158013691.1	TIGR03086 family protein	-
MVAN_RS14745	3109351..3110298	+	948	WP_036372912.1	WYL domain-containing protein	-
MVAN_RS14750	3110429..3111121	-	693	WP_011780145.1	HTH domain-containing protein	-
MVAN_RS14755	3111143..3111547	-	405	WP_036372910.1	nuclear transport factor 2 family protein	-
MVAN_RS14760	3111776..3112585	+	810	WP_011780147.1	LLM class F420-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-105)

Antitoxin

• Antitoxin MazE-like (4-66)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 11972.85 Da
• Isoelectric Point: 8.7573

>T21823 WP_011780141.1 NC_008726:c3108114-3107782 [Mycolicibacterium vanbaalenii PYR-1]
VNRGEIWTVAGGVYAAKPRPAVIVQDDLFDATSSVTVAPMTSTLLDAPLMRIRIAGGDGRLSGLDHDRDVMIDKLTTVRR
SNVHVRVGRLTAEQVVEVERTMMAFLGLAR

Nucleotide

• Length: 333 bp

>T21823 NC_008726:c3108114-3107782 [Mycolicibacterium vanbaalenii PYR-1]
GTGAACCGAGGAGAGATCTGGACCGTAGCGGGCGGCGTCTACGCGGCGAAGCCACGTCCGGCAGTGATCGTTCAGGATGA
CCTCTTTGATGCCACGAGTTCAGTGACTGTTGCTCCGATGACCAGCACGCTGTTGGATGCGCCGCTGATGCGCATTCGGA
TAGCCGGCGGAGACGGTCGGCTATCCGGACTTGACCACGATCGCGACGTGATGATCGACAAGCTCACTACCGTGAGAAGG
TCGAACGTCCACGTCCGGGTCGGCCGGCTGACAGCGGAACAAGTCGTCGAGGTCGAGCGGACAATGATGGCGTTTCTTGG
CCTTGCCCGATAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7932.81 Da
• Isoelectric Point: 4.8146

>AT21823 WP_041306533.1 NC_008726:c3108317-3108111 [Mycolicibacterium vanbaalenii PYR-1]
MAVRDRVGEYRRRMRERGLRPLQVWVPDVRTEAFAAEARRQASLVARADESGDDQNFIEAISTPWDEE

Nucleotide

• Length: 207 bp

>AT21823 NC_008726:c3108317-3108111 [Mycolicibacterium vanbaalenii PYR-1]
ATGGCAGTGAGGGATAGGGTCGGCGAATACCGGCGGCGGATGCGGGAGCGGGGCCTCCGGCCGTTGCAGGTCTGGGTGCC
TGACGTGCGAACCGAGGCTTTTGCGGCGGAGGCGCGTCGCCAGGCTTCGTTGGTCGCGCGAGCCGACGAGAGCGGCGACG
ACCAAAACTTCATTGAGGCGATCTCGACGCCGTGGGACGAGGAGTGA

Structures

Toxin

• AlphaFold DB: A1T986