218223

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3948659..3949473 Replicon chromosome
Accession NZ_CP084205
Organism Escherichia coli strain EC2648-R1

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag LDB14_RS19240 Protein ID WP_001054376.1
Coordinates 3948659..3948916 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag LDB14_RS19245 Protein ID WP_001309181.1
Coordinates 3948928..3949473 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB14_RS19215 (3943947) 3943947..3945053 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
LDB14_RS19220 (3945118) 3945118..3946098 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
LDB14_RS19225 (3946208) 3946208..3946413 + 206 Protein_3777 HNH endonuclease -
LDB14_RS19230 (3946681) 3946681..3947921 - 1241 Protein_3778 helicase YjhR -
LDB14_RS19235 (3948037) 3948037..3948168 + 132 WP_001309182.1 hypothetical protein -
LDB14_RS19240 (3948659) 3948659..3948916 + 258 WP_001054376.1 YjhX family toxin Toxin
LDB14_RS19245 (3948928) 3948928..3949473 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
LDB14_RS19250 (3949529) 3949529..3950275 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
LDB14_RS19255 (3950444) 3950444..3950662 + 219 Protein_3783 hypothetical protein -
LDB14_RS19260 (3950700) 3950700..3950816 + 117 Protein_3784 VOC family protein -
LDB14_RS19265 (3951061) 3951061..3952182 + 1122 WP_000010829.1 M42 family metallopeptidase -
LDB14_RS19270 (3952179) 3952179..3952457 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
LDB14_RS19275 (3952469) 3952469..3953782 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 3937669..3957697 20028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T218223 WP_001054376.1 NZ_CP084205:3948659-3948916 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T218223 NZ_CP115701:2019783-2019885 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT218223 WP_001309181.1 NZ_CP084205:3948928-3949473 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT218223 NZ_CP115701:c2019892-2019747 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References