Detailed information of TA system TA021822

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 1819600..1820270
• Replicon: chromosome
• Accession: NC_008726
• Organism: Mycobacterium vanbaalenii PYR-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A1T5U0
• Locus tag: MVAN_RS08635
• Protein ID: WP_011778960.1
• Coordinates: 1819866..1820270 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MVAN_RS31080
• Protein ID: WP_203431676.1
• Coordinates: 1819600..1819869 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MVAN_RS08600	1814672..1815094	+	423	WP_011778954.1	type II toxin-antitoxin system VapC family toxin	-
MVAN_RS08605	1815105..1815470	-	366	WP_041307712.1	hypothetical protein	-
MVAN_RS08610	1815467..1815835	-	369	WP_011778955.1	chromosome condensation protein CrcB	-
MVAN_RS08615	1815878..1816549	-	672	WP_041306029.1	GtrA family protein	-
MVAN_RS08620	1816635..1817840	+	1206	WP_011778957.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
MVAN_RS08625	1817837..1818337	+	501	WP_011778958.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
MVAN_RS08630	1818584..1819423	+	840	Protein_1730	hypothetical protein	-
MVAN_RS31080	1819600..1819869	+	270	WP_203431676.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MVAN_RS08635	1819866..1820270	+	405	WP_011778960.1	type II toxin-antitoxin system VapC family toxin	Toxin
MVAN_RS30675	1820329..1822686	-	2358	WP_049778060.1	VCBS domain-containing protein	-
MVAN_RS08645	1823011..1823202	-	192	WP_036369580.1	hypothetical protein	-
MVAN_RS08650	1823328..1824497	+	1170	WP_011778962.1	acyl-CoA dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-120)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-66)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14353.63 Da
• Isoelectric Point: 4.7784

>T21822 WP_011778960.1 NC_008726:1819866-1820270 [Mycolicibacterium vanbaalenii PYR-1]
VIYLDTSAMVKLVVAEPESEELIDWLNERLTHDPIVTSIIGRVELHRAALRAGAEAMAAAREVLDGVDTLVLTEPIAALA
GTMVPAELRTLDALHLATAEIHREGLTAICAYDRRLVDAARARKLPVVAPGASV

Nucleotide

• Length: 405 bp

>T21822 NC_008726:1819866-1820270 [Mycolicibacterium vanbaalenii PYR-1]
GTGATCTATCTCGACACTTCAGCGATGGTCAAACTCGTTGTGGCCGAGCCGGAATCCGAGGAACTGATCGATTGGCTCAA
CGAGCGTCTCACGCACGACCCGATAGTCACCAGCATCATCGGTCGCGTCGAGCTGCATCGGGCCGCGTTGCGTGCCGGGG
CGGAAGCGATGGCTGCGGCTCGTGAGGTGCTCGATGGCGTCGACACGCTCGTGCTGACCGAACCCATTGCAGCGTTGGCG
GGCACCATGGTGCCTGCCGAGTTGCGCACACTCGATGCTCTGCACCTGGCGACGGCCGAGATTCACCGGGAAGGCCTTAC
CGCGATCTGCGCATACGACCGTCGTCTCGTCGATGCCGCCCGAGCCCGCAAGCTCCCGGTGGTAGCGCCGGGAGCTTCGG
TGTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9757.16 Da
• Isoelectric Point: 10.9921

>AT21822 WP_203431676.1 NC_008726:1819600-1819869 [Mycolicibacterium vanbaalenii PYR-1]
VERIGVRELRQHASTWVAKAQAGETIEITSRGRLVARLTPVADALVTREALIDSGQLVPAASPRRMFDRARLVDAAPLSA
ILDEQRADR

Nucleotide

• Length: 270 bp

>AT21822 NC_008726:1819600-1819869 [Mycolicibacterium vanbaalenii PYR-1]
GTGGAGCGAATCGGAGTCAGGGAGCTACGACAGCACGCCAGCACGTGGGTGGCCAAAGCGCAGGCAGGTGAGACGATCGA
AATCACCAGTCGCGGCCGCTTGGTGGCGCGCTTGACACCCGTGGCGGATGCTCTGGTCACTCGAGAAGCACTTATCGACT
CCGGCCAACTTGTGCCCGCGGCAAGCCCTCGTCGAATGTTCGATCGCGCACGGCTTGTCGACGCCGCGCCGCTTTCAGCC
ATCCTCGATGAGCAACGCGCGGACCGGTGA

Structures

Toxin

• AlphaFold DB: A1T5U0