Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yafW-ykfI/CbtA-CbeA |
| Location | 3521241..3521920 | Replicon | chromosome |
| Accession | NZ_CP084205 | ||
| Organism | Escherichia coli strain EC2648-R1 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | P77692 |
| Locus tag | LDB14_RS17145 | Protein ID | WP_000854672.1 |
| Coordinates | 3521241..3521582 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | Q47684 |
| Locus tag | LDB14_RS17150 | Protein ID | WP_000070395.1 |
| Coordinates | 3521603..3521920 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LDB14_RS17120 (3516827) | 3516827..3516919 | + | 93 | Protein_3365 | sigma factor-binding protein Crl | - |
| LDB14_RS17125 (3516958) | 3516958..3518013 | - | 1056 | WP_000749863.1 | phosphoporin PhoE | - |
| LDB14_RS17130 (3518301) | 3518301..3519404 | + | 1104 | WP_001285288.1 | glutamate 5-kinase | - |
| LDB14_RS17135 (3519416) | 3519416..3520669 | + | 1254 | WP_000893278.1 | glutamate-5-semialdehyde dehydrogenase | - |
| LDB14_RS17145 (3521241) | 3521241..3521582 | - | 342 | WP_000854672.1 | type IV toxin-antitoxin system toxin YkfI | Toxin |
| LDB14_RS17150 (3521603) | 3521603..3521920 | - | 318 | WP_000070395.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| LDB14_RS17155 (3521939) | 3521939..3522160 | - | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| LDB14_RS17160 (3522169) | 3522169..3522645 | - | 477 | WP_000811693.1 | RadC family protein | - |
| LDB14_RS17165 (3522661) | 3522661..3523119 | - | 459 | WP_000211838.1 | antirestriction protein | - |
| LDB14_RS17170 (3523217) | 3523217..3523456 | - | 240 | WP_000194654.1 | DUF905 family protein | - |
| LDB14_RS17175 (3523533) | 3523533..3524000 | - | 468 | WP_001547765.1 | protein YkfB | - |
| LDB14_RS17180 (3524023) | 3524023..3524466 | - | 444 | WP_000824223.1 | lipoprotein YafY | - |
| LDB14_RS17185 (3524466) | 3524466..3524693 | - | 228 | WP_001548158.1 | protein YpjK | - |
| LDB14_RS17190 (3524689) | 3524689..3524880 | - | 192 | Protein_3378 | DeoR family transcriptional regulator | - |
| LDB14_RS17195 (3525097) | 3525097..3525918 | - | 822 | WP_000197389.1 | DUF932 domain-containing protein | - |
| LDB14_RS17200 (3526010) | 3526010..3526873 | - | 864 | WP_001065553.1 | GTPase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3516121..3554934 | 38813 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12905.01 Da Isoelectric Point: 9.6543
>T218218 WP_000854672.1 NZ_CP084205:c3521582-3521241 [Escherichia coli]
MKTLPAITQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
MKTLPAITQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
Download Length: 342 bp
>T218218 NZ_CP115697:c145893-145408 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAACCGTTAACAAGCTCCCATCAACTTACTGAGTTCGTCAGTGGCGAGGCTGTACTAGA
TGACTGGCTTAAACAGAGAGGATTAAAAAATCAGGCTCTCGGTTCAGCCCGAACGTTTGTTGTTTGTAAAACAGGCACGA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTAGAAGCAACGGGAAATATCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTCGATGTTTCATTCCGTGGAAAAGGGCTCGGAGCTGATTT
ACTGCATGATGCAGTTCTGCGTTGTTACCGTGTAGCTGAAAATATTGGAGTCCGTGCCATTATGGTTCATGCACTGACTG
AAGTGGCCAAAAGCTTTTATCTTCATCATGGTTTTAAGGCATCACAAACCCAGGAGCGGACTTTGTTTCTCAAACTACCA
CAGTAG
GTGGGACGTGTAACAGCACCAGAACCGTTAACAAGCTCCCATCAACTTACTGAGTTCGTCAGTGGCGAGGCTGTACTAGA
TGACTGGCTTAAACAGAGAGGATTAAAAAATCAGGCTCTCGGTTCAGCCCGAACGTTTGTTGTTTGTAAAACAGGCACGA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTAGAAGCAACGGGAAATATCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTCGATGTTTCATTCCGTGGAAAAGGGCTCGGAGCTGATTT
ACTGCATGATGCAGTTCTGCGTTGTTACCGTGTAGCTGAAAATATTGGAGTCCGTGCCATTATGGTTCATGCACTGACTG
AAGTGGCCAAAAGCTTTTATCTTCATCATGGTTTTAAGGCATCACAAACCCAGGAGCGGACTTTGTTTCTCAAACTACCA
CAGTAG
Antitoxin
Download Length: 106 a.a. Molecular weight: 11939.59 Da Isoelectric Point: 6.7391
>AT218218 WP_000070395.1 NZ_CP084205:c3521920-3521603 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFILQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFILQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT218218 NZ_CP115697:c146147-145881 [Enterobacter hormaechei]
ATGAAATCCGATATTCAGCTCAATCTTAGAGCCAAGGAATCGCAAAGAGCACTCATCGATGCTGCTGCAGAGATTCTCCA
TAAATCACGTACAGACTTCATTCTGGAAATGGCATGCCAGGCTGCGGAGAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAGCAGTATGCAGAATTTATCGATATGCTCGATGCACCAGTTTCGGATGATGCTGCCATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA
ATGAAATCCGATATTCAGCTCAATCTTAGAGCCAAGGAATCGCAAAGAGCACTCATCGATGCTGCTGCAGAGATTCTCCA
TAAATCACGTACAGACTTCATTCTGGAAATGGCATGCCAGGCTGCGGAGAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAGCAGTATGCAGAATTTATCGATATGCTCGATGCACCAGTTTCGGATGATGCTGCCATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|