21821

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 1723981..1724561 Replicon chromosome
Accession NC_008726
Organism Mycobacterium vanbaalenii PYR-1

Toxin (Protein)


Gene name doc Uniprot ID A1T5K1
Locus tag MVAN_RS08170 Protein ID WP_011778876.1
Coordinates 1723981..1724367 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2S8LB97
Locus tag MVAN_RS08175 Protein ID WP_036369753.1
Coordinates 1724364..1724561 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MVAN_RS08155 1719127..1720542 + 1416 WP_041305954.1 NAD(P)H-quinone dehydrogenase -
MVAN_RS08160 1720807..1722564 + 1758 WP_011778874.1 glycerol-3-phosphate dehydrogenase/oxidase -
MVAN_RS08165 1722561..1723418 + 858 WP_011778875.1 pseudouridine synthase -
MVAN_RS08170 1723981..1724367 - 387 WP_011778876.1 Fic family protein Toxin
MVAN_RS08175 1724364..1724561 - 198 WP_036369753.1 hypothetical protein Antitoxin
MVAN_RS31055 1724810..1725130 + 321 WP_158013671.1 hypothetical protein -
MVAN_RS08185 1725130..1725900 + 771 WP_011778878.1 SDR family oxidoreductase -
MVAN_RS08190 1725978..1726757 - 780 WP_011778879.1 enoyl-CoA hydratase/isomerase family protein -
MVAN_RS08195 1726768..1727436 - 669 WP_011778880.1 TetR family transcriptional regulator -
MVAN_RS08200 1727506..1728546 + 1041 WP_011778881.1 ferredoxin reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13754.44 Da        Isoelectric Point: 4.1262

>T21821 WP_011778876.1 NC_008726:c1724367-1723981 [Mycolicibacterium vanbaalenii PYR-1]
VTEYLDRDDVLTAGSAAVGQVVHVSDYGLLDAAVARPRATVFGLDAYPDNFTKAAALLQSLARNHALVDGNMPMAWAAAW
IFLHINGISLGEFDVDDAEVFMNNVAINGDLEIDYVANKLNSYAKPAQ

Download         Length: 387 bp

>T21821 NC_008726:c1724367-1723981 [Mycolicibacterium vanbaalenii PYR-1]
GTGACCGAATACCTCGATCGCGATGACGTATTGACAGCAGGATCGGCCGCAGTCGGCCAGGTCGTCCATGTCAGCGACTA
CGGCCTACTTGACGCTGCCGTGGCACGCCCCCGCGCCACTGTCTTCGGGCTCGACGCCTACCCGGACAACTTCACCAAAG
CCGCTGCCTTGCTTCAGTCTTTGGCGCGCAATCACGCCCTGGTGGACGGGAACATGCCGATGGCCTGGGCGGCAGCATGG
ATCTTCCTGCACATCAACGGGATCTCACTGGGTGAGTTCGACGTCGACGACGCCGAAGTATTCATGAACAACGTCGCCAT
CAACGGCGATCTCGAAATCGACTACGTCGCCAATAAGCTCAATTCCTACGCCAAACCGGCACAGTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7074.95 Da        Isoelectric Point: 7.2050

>AT21821 WP_036369753.1 NC_008726:c1724561-1724364 [Mycolicibacterium vanbaalenii PYR-1]
MPSLNVSFTEEELATVRAAAANDEVSLRTFAHAAILSAASEHRRRVAEAARIVAERSAELNRRLA

Download         Length: 198 bp

>AT21821 NC_008726:c1724561-1724364 [Mycolicibacterium vanbaalenii PYR-1]
ATGCCGTCCTTGAATGTCTCGTTCACCGAAGAAGAACTGGCGACCGTCCGCGCAGCGGCCGCCAACGATGAAGTCTCACT
GCGGACGTTCGCACACGCAGCCATTCTCTCTGCCGCGAGCGAGCATCGCCGCCGTGTCGCTGAAGCCGCCCGCATCGTCG
CCGAGCGATCGGCAGAACTCAACCGTCGCCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A1T5K1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S8LB97

References