Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 1243951..1244588 | Replicon | chromosome |
Accession | NC_008726 | ||
Organism | Mycobacterium vanbaalenii PYR-1 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A1T4A6 |
Locus tag | MVAN_RS05900 | Protein ID | WP_011778440.1 |
Coordinates | 1244193..1244588 (+) | Length | 132 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A1T4A5 |
Locus tag | MVAN_RS05895 | Protein ID | WP_011778439.1 |
Coordinates | 1243951..1244196 (+) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MVAN_RS05875 | 1239808..1240347 | + | 540 | WP_011778435.1 | YceI family protein | - |
MVAN_RS05880 | 1240369..1241958 | - | 1590 | WP_011778436.1 | MFS transporter | - |
MVAN_RS05885 | 1241962..1242975 | - | 1014 | WP_011778437.1 | TIGR03617 family F420-dependent LLM class oxidoreductase | - |
MVAN_RS05890 | 1242998..1243606 | - | 609 | WP_011778438.1 | TetR/AcrR family transcriptional regulator | - |
MVAN_RS05895 | 1243951..1244196 | + | 246 | WP_011778439.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
MVAN_RS05900 | 1244193..1244588 | + | 396 | WP_011778440.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
MVAN_RS05905 | 1244661..1248023 | - | 3363 | WP_011778441.1 | AAA family ATPase | - |
MVAN_RS05910 | 1248016..1248705 | - | 690 | WP_011778442.1 | DUF4194 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14077.85 Da Isoelectric Point: 4.4150
>T21820 WP_011778440.1 NC_008726:1244193-1244588 [Mycolicibacterium vanbaalenii PYR-1]
MIADSSAIIAILRDEDDAVDYARALAAADVRRLSAASYLECGIVLDAQRDPVVSRALDELIDEAAMTIEPVTERQAKLAR
RAYADFGKGSGHPAGLNFGDCLSYALALDRREPLLWKGNDFGHTGIASALE
MIADSSAIIAILRDEDDAVDYARALAAADVRRLSAASYLECGIVLDAQRDPVVSRALDELIDEAAMTIEPVTERQAKLAR
RAYADFGKGSGHPAGLNFGDCLSYALALDRREPLLWKGNDFGHTGIASALE
Download Length: 396 bp
>T21820 NC_008726:1244193-1244588 [Mycolicibacterium vanbaalenii PYR-1]
ATGATCGCCGATTCGTCGGCGATCATCGCGATTCTGCGGGACGAGGACGATGCGGTCGATTACGCCAGAGCGCTCGCCGC
CGCCGACGTACGTCGACTGTCCGCGGCCAGCTATCTCGAGTGCGGGATCGTGCTCGACGCGCAGCGCGATCCGGTCGTGA
GCAGAGCTCTTGACGAACTGATCGATGAAGCTGCGATGACGATCGAGCCGGTGACCGAGCGCCAGGCCAAATTGGCGCGC
CGAGCGTATGCCGATTTCGGGAAAGGGAGCGGGCATCCGGCCGGATTGAACTTCGGCGACTGCCTGTCGTACGCGTTGGC
GCTGGATCGTCGTGAACCACTTCTGTGGAAAGGCAACGACTTCGGGCACACCGGCATCGCGTCCGCACTCGAGTAA
ATGATCGCCGATTCGTCGGCGATCATCGCGATTCTGCGGGACGAGGACGATGCGGTCGATTACGCCAGAGCGCTCGCCGC
CGCCGACGTACGTCGACTGTCCGCGGCCAGCTATCTCGAGTGCGGGATCGTGCTCGACGCGCAGCGCGATCCGGTCGTGA
GCAGAGCTCTTGACGAACTGATCGATGAAGCTGCGATGACGATCGAGCCGGTGACCGAGCGCCAGGCCAAATTGGCGCGC
CGAGCGTATGCCGATTTCGGGAAAGGGAGCGGGCATCCGGCCGGATTGAACTTCGGCGACTGCCTGTCGTACGCGTTGGC
GCTGGATCGTCGTGAACCACTTCTGTGGAAAGGCAACGACTTCGGGCACACCGGCATCGCGTCCGCACTCGAGTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 8869.00 Da Isoelectric Point: 6.4631
>AT21820 WP_011778439.1 NC_008726:1243951-1244196 [Mycolicibacterium vanbaalenii PYR-1]
MALNIKDEKVHDAVKQLARLTGESQAQAVATAVQERLSRVQQDDLAERLLALGRRTAQRMTSATKNLDHGELLYDDAGLP
G
MALNIKDEKVHDAVKQLARLTGESQAQAVATAVQERLSRVQQDDLAERLLALGRRTAQRMTSATKNLDHGELLYDDAGLP
G
Download Length: 246 bp
>AT21820 NC_008726:1243951-1244196 [Mycolicibacterium vanbaalenii PYR-1]
ATGGCGTTGAACATCAAGGATGAGAAGGTCCACGACGCGGTGAAACAGCTCGCACGCCTCACCGGGGAGTCTCAAGCTCA
GGCGGTGGCGACAGCGGTGCAGGAGCGGTTGTCCAGAGTCCAGCAGGACGATCTCGCGGAACGCCTTCTAGCCCTCGGAC
GCAGGACCGCGCAGCGAATGACGTCGGCAACCAAGAACCTCGACCATGGCGAGTTGCTCTACGACGATGCGGGACTACCG
GGATGA
ATGGCGTTGAACATCAAGGATGAGAAGGTCCACGACGCGGTGAAACAGCTCGCACGCCTCACCGGGGAGTCTCAAGCTCA
GGCGGTGGCGACAGCGGTGCAGGAGCGGTTGTCCAGAGTCCAGCAGGACGATCTCGCGGAACGCCTTCTAGCCCTCGGAC
GCAGGACCGCGCAGCGAATGACGTCGGCAACCAAGAACCTCGACCATGGCGAGTTGCTCTACGACGATGCGGGACTACCG
GGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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