Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1243951..1244588 Replicon chromosome
Accession NC_008726
Organism Mycobacterium vanbaalenii PYR-1

Toxin (Protein)


Gene name vapC Uniprot ID A1T4A6
Locus tag MVAN_RS05900 Protein ID WP_011778440.1
Coordinates 1244193..1244588 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A1T4A5
Locus tag MVAN_RS05895 Protein ID WP_011778439.1
Coordinates 1243951..1244196 (+) Length 82 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MVAN_RS05875 1239808..1240347 + 540 WP_011778435.1 YceI family protein -
MVAN_RS05880 1240369..1241958 - 1590 WP_011778436.1 MFS transporter -
MVAN_RS05885 1241962..1242975 - 1014 WP_011778437.1 TIGR03617 family F420-dependent LLM class oxidoreductase -
MVAN_RS05890 1242998..1243606 - 609 WP_011778438.1 TetR/AcrR family transcriptional regulator -
MVAN_RS05895 1243951..1244196 + 246 WP_011778439.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MVAN_RS05900 1244193..1244588 + 396 WP_011778440.1 type II toxin-antitoxin system VapC family toxin Toxin
MVAN_RS05905 1244661..1248023 - 3363 WP_011778441.1 AAA family ATPase -
MVAN_RS05910 1248016..1248705 - 690 WP_011778442.1 DUF4194 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-123)

Antitoxin

(1-80)


Sequences


Toxin        


Download         Length: 132 a.a.        Molecular weight: 14077.85 Da        Isoelectric Point: 4.4150

>T21820 WP_011778440.1 NC_008726:1244193-1244588 [Mycolicibacterium vanbaalenii PYR-1]
MIADSSAIIAILRDEDDAVDYARALAAADVRRLSAASYLECGIVLDAQRDPVVSRALDELIDEAAMTIEPVTERQAKLAR
RAYADFGKGSGHPAGLNFGDCLSYALALDRREPLLWKGNDFGHTGIASALE

Download         Length: 396 bp

>T21820 NC_008726:1244193-1244588 [Mycolicibacterium vanbaalenii PYR-1]
ATGATCGCCGATTCGTCGGCGATCATCGCGATTCTGCGGGACGAGGACGATGCGGTCGATTACGCCAGAGCGCTCGCCGC
CGCCGACGTACGTCGACTGTCCGCGGCCAGCTATCTCGAGTGCGGGATCGTGCTCGACGCGCAGCGCGATCCGGTCGTGA
GCAGAGCTCTTGACGAACTGATCGATGAAGCTGCGATGACGATCGAGCCGGTGACCGAGCGCCAGGCCAAATTGGCGCGC
CGAGCGTATGCCGATTTCGGGAAAGGGAGCGGGCATCCGGCCGGATTGAACTTCGGCGACTGCCTGTCGTACGCGTTGGC
GCTGGATCGTCGTGAACCACTTCTGTGGAAAGGCAACGACTTCGGGCACACCGGCATCGCGTCCGCACTCGAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8869.00 Da        Isoelectric Point: 6.4631

>AT21820 WP_011778439.1 NC_008726:1243951-1244196 [Mycolicibacterium vanbaalenii PYR-1]
MALNIKDEKVHDAVKQLARLTGESQAQAVATAVQERLSRVQQDDLAERLLALGRRTAQRMTSATKNLDHGELLYDDAGLP
G

Download         Length: 246 bp

>AT21820 NC_008726:1243951-1244196 [Mycolicibacterium vanbaalenii PYR-1]
ATGGCGTTGAACATCAAGGATGAGAAGGTCCACGACGCGGTGAAACAGCTCGCACGCCTCACCGGGGAGTCTCAAGCTCA
GGCGGTGGCGACAGCGGTGCAGGAGCGGTTGTCCAGAGTCCAGCAGGACGATCTCGCGGAACGCCTTCTAGCCCTCGGAC
GCAGGACCGCGCAGCGAATGACGTCGGCAACCAAGAACCTCGACCATGGCGAGTTGCTCTACGACGATGCGGGACTACCG
GGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A1T4A6


Antitoxin

Source ID Structure
AlphaFold DB A1T4A5

References