Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 5476461..5477026 Replicon chromosome
Accession NZ_CP084204
Organism Streptomyces tanashiensis strain Kala

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LDH80_RS24890 Protein ID WP_190106605.1
Coordinates 5476655..5477026 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag LDH80_RS24885 Protein ID WP_190106604.1
Coordinates 5476461..5476658 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH80_RS24865 (LDH80_24840) 5473479..5474150 + 672 WP_229885612.1 hypothetical protein -
LDH80_RS24870 (LDH80_24845) 5474242..5474628 - 387 WP_190106602.1 phage holin family protein -
LDH80_RS24880 (LDH80_24855) 5474941..5476428 + 1488 WP_190106603.1 MFS transporter -
LDH80_RS24885 (LDH80_24860) 5476461..5476658 + 198 WP_190106604.1 Arc family DNA-binding protein Antitoxin
LDH80_RS24890 (LDH80_24865) 5476655..5477026 + 372 WP_190106605.1 Fic family protein Toxin
LDH80_RS24895 (LDH80_24870) 5477174..5478967 + 1794 WP_189805238.1 DEAD/DEAH box helicase -
LDH80_RS24900 (LDH80_24875) 5479382..5480023 + 642 WP_041129456.1 helix-turn-helix domain-containing protein -
LDH80_RS24905 (LDH80_24880) 5480078..5481025 - 948 WP_190106606.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-81)

Antitoxin

Arc-like DNA binding domain

(5-31)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13663.47 Da        Isoelectric Point: 4.8214

>T218194 WP_190106605.1 NZ_CP084204:5476655-5477026 [Streptomyces tanashiensis]
VTHYLTLPELLNLAERLGANEVRDYGLLDSALARPQSSVFGQDAYPDVWQKAAALMESLSRNHGLVDGNKRIAWYATWVF
LHMNGHPLDPGFDVDEAESFVLDVCQGALDVPKIAAQLPRFAR

Download         Length: 372 bp

>T218194 NZ_CP115673:c26959-26543 [Enterobacter hormaechei]
GTGAACAAGATCTATATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATCGTGGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCGCCGCGCCACGTCCAGCTGGTCGATGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGAT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCACTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCATGCCATCGCCGCCGGCGCGGTACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7407.24 Da        Isoelectric Point: 5.1114

>AT218194 WP_190106604.1 NZ_CP084204:5476461-5476658 [Streptomyces tanashiensis]
MAGLNVRFTEEELDALRERAEAEGRSMQSFAHDAVIRAINEHSRLFNEAAEHVLKASEELNRRLA

Download         Length: 198 bp

>AT218194 NZ_CP115673:c27186-26956 [Enterobacter hormaechei]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGGTCGTTCGCGCAGCTCG
AAAAAGCCGATCCGGACTTTATGGCGGAGCGCGGGGACGTTGTCAGCGACGAAGGAAGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References