Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 550927..551837 Replicon plasmid pCB1A
Accession NZ_CP084198
Organism Pantoea agglomerans strain CB1

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LDO72_RS22015 Protein ID WP_069026891.1
Coordinates 551367..551837 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LDO72_RS22010 Protein ID WP_064703869.1
Coordinates 550927..551370 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO72_RS21980 (LDO72_22000) 545996..546844 - 849 WP_022624593.1 transporter substrate-binding domain-containing protein -
LDO72_RS21985 (LDO72_22005) 546866..548053 - 1188 WP_275103204.1 M20 family metallopeptidase -
LDO72_RS21990 (LDO72_22010) 548295..549194 - 900 WP_163794437.1 alpha/beta hydrolase -
LDO72_RS21995 (LDO72_22015) 549245..549859 - 615 WP_045139957.1 TetR/AcrR family transcriptional regulator -
LDO72_RS22000 (LDO72_22020) 550073..550490 + 418 Protein_528 LysR substrate-binding domain-containing protein -
LDO72_RS22005 (LDO72_22025) 550525..550782 - 258 Protein_529 aldo/keto reductase -
LDO72_RS22010 (LDO72_22030) 550927..551370 + 444 WP_064703869.1 DUF2384 domain-containing protein Antitoxin
LDO72_RS22015 (LDO72_22035) 551367..551837 + 471 WP_069026891.1 RES family NAD+ phosphorylase Toxin
LDO72_RS22020 (LDO72_22040) 552009..553040 + 1032 WP_010670602.1 AI-2E family transporter -
LDO72_RS22025 (LDO72_22045) 553029..555758 - 2730 WP_275103205.1 cation-transporting P-type ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..569555 569555


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre

(16-147)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17466.90 Da        Isoelectric Point: 4.7699

>T218192 WP_069026891.1 NZ_CP084198:551367-551837 [Pantoea agglomerans]
MILYRLTKTKYLSTAWTGFGAKEAGGRWNSIGISMVYVSETASLTLLETLVHLHSAHILDAFTLLRIDVPDALIQTADIT
ELPANWADEDAPAELADYGDAWCSACDAVALRVPSALSPVEYNYLLNPEHPDFFRIVQQAEAIPFRFDRRLKPDRK

Download         Length: 471 bp

>T218192 NZ_CP115672:c3795425-3795015 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGCGCGCCGTGGATGCTTAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16463.84 Da        Isoelectric Point: 9.9250

>AT218192 WP_064703869.1 NZ_CP084198:550927-551370 [Pantoea agglomerans]
MKTFSFSANKTRAPRLWQAAGLNNADGVALLGQINEGLDGNVAHLIVNWAKITQNDLRKMSGIPSTTFSRSVKAKFSAEQ
SERLVRIIRVIDRAVELFEGDKDEAQKWLNEPNRALSWKMPAELMASETGAYEVMKLITRLEHGVYS

Download         Length: 444 bp

>AT218192 NZ_CP115672:c3795672-3795406 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References