Detailed information of TA system TA021819

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1217632..1218196
• Replicon: chromosome
• Accession: NC_008726
• Organism: Mycobacterium vanbaalenii PYR-1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MVAN_RS05755
• Protein ID: WP_041305787.1
• Coordinates: 1217632..1217982 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A1T480
• Locus tag: MVAN_RS05760
• Protein ID: WP_011778414.1
• Coordinates: 1217966..1218196 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MVAN_RS05740	1213479..1213868	-	390	WP_011778410.1	ParD-like family protein	-
MVAN_RS05745	1213956..1214879	-	924	WP_011778411.1	ribonuclease H	-
MVAN_RS05750	1214954..1217500	-	2547	WP_041307582.1	SEC-C domain-containing protein	-
MVAN_RS05755	1217632..1217982	-	351	WP_041305787.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MVAN_RS05760	1217966..1218196	-	231	WP_011778414.1	ribbon-helix-helix domain-containing protein	Antitoxin
MVAN_RS05765	1218412..1220067	+	1656	WP_011778415.1	NERD domain-containing protein	-
MVAN_RS05770	1220129..1221004	+	876	WP_011778416.1	hypothetical protein	-
MVAN_RS30640	1221391..1222131	+	741	WP_011778417.1	hypothetical protein	-
MVAN_RS05785	1222168..1222434	-	267	WP_011778418.1	hypothetical protein	-
MVAN_RS05790	1222431..1222718	-	288	WP_203431696.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1150236..1218585	68349

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-116)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-38)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12643.47 Da
• Isoelectric Point: 10.8246

>T21819 WP_041305787.1 NC_008726:c1217982-1217632 [Mycolicibacterium vanbaalenii PYR-1]
VMQRGDIWYVDLEPSRASEANKTRPAVIVSNDRANATASRLGRGVISVVPVTSNVDRVYPFQVLLQAPDSGLAVASKAQA
EQVRSIAAQRLIRRIGRVSARELAELDDALRLHLAL

Nucleotide

• Length: 351 bp

>T21819 NC_008726:c1217982-1217632 [Mycolicibacterium vanbaalenii PYR-1]
GTGATGCAGCGCGGTGACATCTGGTACGTCGATCTGGAGCCGTCCCGAGCGAGCGAGGCCAACAAGACGCGACCTGCCGT
CATTGTCAGCAATGACCGAGCCAACGCCACCGCATCGAGGCTCGGCCGCGGGGTGATTTCCGTCGTGCCGGTAACCAGCA
ACGTCGACAGGGTCTATCCATTCCAGGTGCTTCTCCAAGCCCCCGACAGCGGGTTGGCGGTTGCGTCAAAGGCGCAGGCC
GAACAGGTCAGATCAATTGCTGCACAGCGGTTGATCCGCCGGATCGGCCGTGTCTCCGCGCGTGAACTTGCAGAACTGGA
TGACGCTCTGCGGCTGCATCTCGCACTGTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8155.97 Da
• Isoelectric Point: 4.0197

>AT21819 WP_011778414.1 NC_008726:c1218196-1217966 [Mycolicibacterium vanbaalenii PYR-1]
MKISISLSEDEIALVDAYVDHAGLPSRSAAIQKAIRMLRYPTLEDDYVQAWGEWSSGGEGDVWESAAGDGVGDAAR

Nucleotide

• Length: 231 bp

>AT21819 NC_008726:c1218196-1217966 [Mycolicibacterium vanbaalenii PYR-1]
ATGAAGATCAGCATCAGCCTCTCGGAAGACGAGATCGCGCTGGTCGACGCCTACGTCGACCACGCGGGCCTTCCGTCGCG
GTCGGCGGCGATTCAGAAAGCAATCCGGATGCTGCGCTACCCGACACTGGAGGACGACTACGTGCAGGCCTGGGGCGAGT
GGTCGAGCGGCGGCGAGGGCGATGTGTGGGAATCCGCCGCCGGAGACGGCGTCGGTGATGCAGCGCGGTGA

Structures

Antitoxin

• AlphaFold DB: A1T480