Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3164808..3165425 | Replicon | chromosome |
Accession | NZ_CP084197 | ||
Organism | Pantoea agglomerans strain CB1 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | E0LTU7 |
Locus tag | LDO72_RS15005 | Protein ID | WP_003850458.1 |
Coordinates | 3165210..3165425 (+) | Length | 72 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | E0LTU8 |
Locus tag | LDO72_RS15000 | Protein ID | WP_003850455.1 |
Coordinates | 3164808..3165185 (+) | Length | 126 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LDO72_RS14970 (LDO72_14975) | 3161115..3161369 | + | 255 | WP_010671219.1 | type B 50S ribosomal protein L31 | - |
LDO72_RS14975 (LDO72_14980) | 3161381..3161521 | + | 141 | WP_010255896.1 | type B 50S ribosomal protein L36 | - |
LDO72_RS14980 (LDO72_14985) | 3161567..3162445 | - | 879 | WP_250863483.1 | metal ABC transporter substrate-binding protein | - |
LDO72_RS14985 (LDO72_14990) | 3162461..3163300 | - | 840 | WP_010255890.1 | metal ABC transporter permease | - |
LDO72_RS14990 (LDO72_14995) | 3163297..3163965 | - | 669 | WP_069026576.1 | ABC transporter ATP-binding protein | - |
LDO72_RS14995 (LDO72_15000) | 3164307..3164660 | + | 354 | WP_275102480.1 | hypothetical protein | - |
LDO72_RS15000 (LDO72_15005) | 3164808..3165185 | + | 378 | WP_003850455.1 | Hha toxicity modulator TomB | Antitoxin |
LDO72_RS15005 (LDO72_15010) | 3165210..3165425 | + | 216 | WP_003850458.1 | HHA domain-containing protein | Toxin |
LDO72_RS15015 (LDO72_15020) | 3165832..3166143 | + | 312 | WP_031592174.1 | MGMT family protein | - |
LDO72_RS15020 (LDO72_15025) | 3166183..3166740 | - | 558 | WP_010255881.1 | YbaY family lipoprotein | - |
LDO72_RS15025 (LDO72_15030) | 3166931..3167794 | + | 864 | WP_010255880.1 | acyl-CoA thioesterase II | - |
LDO72_RS15030 (LDO72_15035) | 3167845..3169131 | - | 1287 | WP_010255877.1 | ammonium transporter AmtB | - |
LDO72_RS15035 (LDO72_15040) | 3169166..3169504 | - | 339 | WP_003850469.1 | P-II family nitrogen regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 72 a.a. Molecular weight: 8510.90 Da Isoelectric Point: 9.4825
>T218187 WP_003850458.1 NZ_CP084197:3165210-3165425 [Pantoea agglomerans]
MNKTLTKTDYLMRLRRCRSLDTLERVIEKNKYELPEDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR
MNKTLTKTDYLMRLRRCRSLDTLERVIEKNKYELPEDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR
Download Length: 216 bp
>T218187 NZ_CP115672:c303531-303229 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATAGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATAGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 14636.25 Da Isoelectric Point: 4.3976
>AT218187 WP_003850455.1 NZ_CP084197:3164808-3165185 [Pantoea agglomerans]
MDEYSPKRHDIAQLKYLCESLFDDSMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDEALISQIDEYL
DDTFMLFSNYGVNSPDLQRWQRSAKRLFNLFTEECAFLQQPSHSL
MDEYSPKRHDIAQLKYLCESLFDDSMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDEALISQIDEYL
DDTFMLFSNYGVNSPDLQRWQRSAKRLFNLFTEECAFLQQPSHSL
Download Length: 378 bp
>AT218187 NZ_CP115672:c303222-302935 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1I5AGC3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1I5AG55 |