Detailed information of TA system TA218186

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 3098394..3099160
• Replicon: chromosome
• Accession: NZ_CP084197
• Organism: Pantoea agglomerans strain CB1

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: LDO72_RS14675
• Protein ID: WP_275102464.1
• Coordinates: 3098394..3098762 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: LDO72_RS14680
• Protein ID: WP_191914503.1
• Coordinates: 3098825..3099160 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO72_RS14650 (LDO72_14655)	3094338..3094670	+	333	WP_163792414.1	SymE family type I addiction module toxin	-
LDO72_RS14655 (LDO72_14660)	3094980..3095303	-	324	WP_275102463.1	hypothetical protein	-
LDO72_RS14660 (LDO72_14665)	3095723..3096049	+	327	WP_072036911.1	four-helix bundle copper-binding protein	-
LDO72_RS14665 (LDO72_14670)	3096474..3096701	+	228	WP_275103091.1	DUF333 domain-containing protein	-
LDO72_RS14670 (LDO72_14675)	3097427..3098260	-	834	WP_176971330.1	DUF4942 domain-containing protein	-
LDO72_RS14675 (LDO72_14680)	3098394..3098762	-	369	WP_275102464.1	TA system toxin CbtA family protein	Toxin
LDO72_RS14680 (LDO72_14685)	3098825..3099160	-	336	WP_191914503.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LDO72_RS14685 (LDO72_14690)	3099172..3099651	-	480	WP_176971328.1	DNA repair protein RadC	-
LDO72_RS14690 (LDO72_14695)	3099834..3100454	-	621	WP_176971327.1	hypothetical protein	-
LDO72_RS14695 (LDO72_14700)	3100482..3101036	-	555	WP_176971326.1	hypothetical protein	-
LDO72_RS14700 (LDO72_14705)	3101279..3102163	-	885	WP_176971325.1	50S ribosome-binding GTPase	-
LDO72_RS14705 (LDO72_14710)	3102271..3103071	-	801	WP_275102465.1	hypothetical protein	-
LDO72_RS14710 (LDO72_14715)	3103687..3103896	+	210	WP_275102466.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3097427..3114438	17011

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13624.64 Da
• Isoelectric Point: 6.8598

>T218186 WP_275102464.1 NZ_CP084197:c3098762-3098394 [Pantoea agglomerans]
MQTLPVTPKGATYACPSPVVVWQSMLKYLLEQHYGLALNDTEFSDDAVIHEHIDAGISLADALNFTVEKFDLVRIDRRGF
SCQAHSPFITAIDILRARRATGLMTRLGYQTITSVIRGEKQT

Nucleotide

• Length: 369 bp

>T218186 NZ_CP115672:c303222-302935 [Enterobacter hormaechei]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12223.91 Da
• Isoelectric Point: 7.0366

>AT218186 WP_191914503.1 NZ_CP084197:c3099160-3098825 [Pantoea agglomerans]
MSSITTPAWGLKRNVTPQLGARLVQKGARLHFLADRADISGTFSEAQVRDLDNAFPQFINHLELMLLSGELNPCHQHCVT
LYHKGLTCEADSLGSHGYVYLAIYPTPQSTA

Nucleotide

• Length: 336 bp

>AT218186 NZ_CP115672:c303531-303229 [Enterobacter hormaechei]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATAGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA