Detailed information of TA system TA218184

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 2224574..2225204
• Replicon: chromosome
• Accession: NZ_CP084197
• Organism: Pantoea agglomerans strain CB1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A379AGD8
• Locus tag: LDO72_RS10455
• Protein ID: WP_010245321.1
• Coordinates: 2225022..2225204 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LDO72_RS10450
• Protein ID: WP_039391916.1
• Coordinates: 2224574..2224999 (-)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO72_RS10435 (LDO72_10420)	2219778..2220932	+	1155	WP_010245312.1	efflux RND transporter periplasmic adaptor subunit	-
LDO72_RS10440 (LDO72_10425)	2220945..2224097	+	3153	WP_010670097.1	multidrug efflux RND transporter permease subunit OqxB	-
LDO72_RS10445 (LDO72_10430)	2224185..2224538	-	354	WP_039391918.1	type II toxin-antitoxin system HicB family antitoxin	-
LDO72_RS10450 (LDO72_10435)	2224574..2224999	-	426	WP_039391916.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LDO72_RS10455 (LDO72_10440)	2225022..2225204	-	183	WP_010245321.1	type II toxin-antitoxin system HicA family toxin	Toxin
LDO72_RS10460 (LDO72_10445)	2225400..2225894	-	495	WP_010245324.1	Rrf2 family transcriptional regulator	-
LDO72_RS10465 (LDO72_10450)	2226102..2227286	-	1185	WP_134160010.1	MFS transporter	-
LDO72_RS10470 (LDO72_10455)	2227489..2228418	+	930	WP_033771708.1	DNA replication terminus site-binding protein	-
LDO72_RS10475 (LDO72_10460)	2228462..2229859	-	1398	WP_010245332.1	class II fumarate hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-82)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7000.12 Da
• Isoelectric Point: 11.0643

>T218184 WP_010245321.1 NZ_CP084197:c2225204-2225022 [Pantoea agglomerans]
MKYSEFRRWLIQQGAILTKHRSGSSHFKVFLGDRQSIFPDHGAKEMPEGTRRKILKDLGL

Nucleotide

• Length: 183 bp

>T218184 NZ_CP115671:2837640-2837900 [Brevundimonas vesicularis]
ATGAAGCTGACCTTCCAGACCTACGGGTGGGAGGATTACCTTCACTGGCAAGACCATGATCGAAAGATGCTGCGAAAGCT
CAATCGGCTGATCATGGAATGCCAGCGGACGCCTTTTTCCGGGACTGGAAAGCCAGAACCCTTGAAGGGCGATTTTGCGG
GATGGTGGTCGCGACGCATCGACCGGGAACATCGGCTCGTCTATCGCGTGACGGACGATGCGCTTTTGATCGCCCAATGC
CGCTATCACTACGACCGATGA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15471.73 Da
• Isoelectric Point: 4.8263

>AT218184 WP_039391916.1 NZ_CP084197:c2224999-2224574 [Pantoea agglomerans]
MFNYAVRLTHDAKTDTYEVSCRDLPLLHSVGDTVEEALAEAEDGLVTAISLEMDTRRPIPVASKPLEGEYIVSVPVLVAM
KAALYNAMIETGTRKADLARQLGVNGPQVDRLLDVEHSSKVENVELALAQLGRKARIEIRT

Nucleotide

• Length: 426 bp

>AT218184 NZ_CP115671:2837386-2837643 [Brevundimonas vesicularis]
ATGAATGCGATGTCCGTCACCGAACTCCGCAAGAACCTCGCCGCGGCCATCGACCGGGTGACGGCGGATCATGACTATAC
CATCATCACACGCGAAGGCGGTAAGCCGGCGGCGGTGCTGATGTCGCTGGAGGACTTCGCCTCGTGGCAGGAGACGGAGT
ATCTGCTGCGCAGCCCGGCGAACGCCGCGCGGTTGCGTGAAGCGATCGCCGAACTCGATGAGGGCGGCGGTCAGGTTCGC
GAACTGATCGAAGAATGA

Structures

Toxin

• AlphaFold DB: A0A379AGD8