Detailed information of TA system TA218183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2105748..2107309
• Replicon: chromosome
• Accession: NZ_CP084197
• Organism: Pantoea agglomerans strain CB1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LDO72_RS09895
• Protein ID: WP_275102226.1
• Coordinates: 2105996..2107309 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LDO72_RS09890
• Protein ID: WP_022625644.1
• Coordinates: 2105748..2105996 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO72_RS09870 (LDO72_09855)	2100995..2103220	+	2226	WP_275102223.1	iron ABC transporter permease	-
LDO72_RS09875 (LDO72_09860)	2103217..2104278	+	1062	WP_163843613.1	ABC transporter ATP-binding protein	-
LDO72_RS09880 (LDO72_09865)	2104302..2105096	+	795	WP_275102224.1	inositol monophosphatase family protein	-
LDO72_RS09885 (LDO72_09870)	2105130..2105567	-	438	WP_275102225.1	GNAT family N-acetyltransferase	-
LDO72_RS09890 (LDO72_09875)	2105748..2105996	+	249	WP_022625644.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LDO72_RS09895 (LDO72_09880)	2105996..2107309	+	1314	WP_275102226.1	type II toxin-antitoxin system HipA family toxin	Toxin
LDO72_RS09900 (LDO72_09885)	2107414..2107620	+	207	WP_010244885.1	type II toxin-antitoxin system MqsA family antitoxin	-
LDO72_RS09905 (LDO72_09890)	2107947..2109368	+	1422	WP_275102227.1	M24 family metallopeptidase	-
LDO72_RS09910 (LDO72_09895)	2109444..2111489	+	2046	WP_031592300.1	FUSC family protein	-
LDO72_RS09915 (LDO72_09900)	2111880..2112215	-	336	WP_275102228.1	gamma-glutamylcyclotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (9-54)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49151.78 Da
• Isoelectric Point: 8.8383

>T218183 WP_275102226.1 NZ_CP084197:2105996-2107309 [Pantoea agglomerans]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTAWLSNPLSRPLSLSMPLQVKAITSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDETRLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTDEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGQMRALAVERFDRRW
SRDKTRLIRLPQEDFCQALGLPSSTKYESDGGPGITEIMQILMGSSNAIEDRYRFMMFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDVMSAYPVLGGTGLNKRALKLAMGLRATKGKKTEIDKIFPRHFIATAKSVSFDRDSLQQIFDFFIKAFP
QAVVSVRDALPPGFPQHIADAIFSHSLIMLERLRHKE

Nucleotide

• Length: 1314 bp

>T218183 NZ_CP115671:2837386-2837643 [Brevundimonas vesicularis]
ATGAATGCGATGTCCGTCACCGAACTCCGCAAGAACCTCGCCGCGGCCATCGACCGGGTGACGGCGGATCATGACTATAC
CATCATCACACGCGAAGGCGGTAAGCCGGCGGCGGTGCTGATGTCGCTGGAGGACTTCGCCTCGTGGCAGGAGACGGAGT
ATCTGCTGCGCAGCCCGGCGAACGCCGCGCGGTTGCGTGAAGCGATCGCCGAACTCGATGAGGGCGGCGGTCAGGTTCGC
GAACTGATCGAAGAATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9363.61 Da
• Isoelectric Point: 5.0775

>AT218183 WP_022625644.1 NZ_CP084197:2105748-2105996 [Pantoea agglomerans]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQSLELSLEVQEKEEASAPQLHDED
EW

Nucleotide

• Length: 249 bp

>AT218183 NZ_CP115671:2837640-2837900 [Brevundimonas vesicularis]
ATGAAGCTGACCTTCCAGACCTACGGGTGGGAGGATTACCTTCACTGGCAAGACCATGATCGAAAGATGCTGCGAAAGCT
CAATCGGCTGATCATGGAATGCCAGCGGACGCCTTTTTCCGGGACTGGAAAGCCAGAACCCTTGAAGGGCGATTTTGCGG
GATGGTGGTCGCGACGCATCGACCGGGAACATCGGCTCGTCTATCGCGTGACGGACGATGCGCTTTTGATCGCCCAATGC
CGCTATCACTACGACCGATGA