Detailed information of TA system TA218180

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 54016..54641
• Replicon: plasmid unnamed1
• Accession: NZ_CP084195
• Organism: Salmonella sp. A39

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LDO68_RS24200
• Protein ID: WP_000911322.1
• Coordinates: 54243..54641 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LDO68_RS24195
• Protein ID: WP_000450265.1
• Coordinates: 54016..54243 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO68_RS24195	54016..54243	+	228	WP_000450265.1	toxin-antitoxin system antitoxin VapB	Antitoxin
LDO68_RS24200	54243..54641	+	399	WP_000911322.1	type II toxin-antitoxin system VapC family toxin	Toxin
LDO68_RS24205	54650..56812	-	2163	WP_000009318.1	type IV conjugative transfer system coupling protein TraD	-
LDO68_RS24210	57189..57920	-	732	WP_000782438.1	conjugal transfer complement resistance protein TraT	-
LDO68_RS24215	57956..58450	-	495	WP_010999946.1	entry exclusion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	spvB / spvC / fdeC / pefB / pefA / pefC / pefD / rck	1..93861	93861

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14887.13 Da
• Isoelectric Point: 8.5264

>T218180 WP_000911322.1 NZ_CP084195:54243-54641 [Salmonella sp. A39]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLDVLDYDTPAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVGGLRTEDWS

Nucleotide

• Length: 399 bp

>T218180 NZ_CP084195:54243-54641 [Salmonella sp. A39]
ATGCTGAAGTTTATGCTGGATACTAACATCTGCATTTTCACGATAAAAAACAAACCTGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGCTCGGTCACCCTGATGGAGCTGATTTACGGCGCCGAAAAAAGCCAGATGCCCG
AAAGAAATCTCGCTGTGATAGAGGGGTTTGTTTCCCGACTTGATGTTCTGGATTATGACACGCCGGCCGCCACCCATACG
GGGCAGATCAGGGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTCGATCAGATGATTGCCGGTCACGCACGCAG
CCGGGGACTGATTGTTGTCACGAACAACACCCGGGAGTTTGAACGTGTGGGTGGACTGAGAACTGAGGACTGGAGCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8509.49 Da
• Isoelectric Point: 4.5358

>AT218180 WP_000450265.1 NZ_CP084195:54016-54243 [Salmonella sp. A39]
METSVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGESWDEWFDGNNVSADFMDNREQPSVQERESF

Nucleotide

• Length: 228 bp

>AT218180 NZ_CP084195:54016-54243 [Salmonella sp. A39]
ATGGAAACCAGCGTATTTCTCAGTAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCAGTGGCTTTGCCGGAAAATGTAAA
ACGTGTGGAAGTTATCGCTGTCGGGCGAACCCGAATTATCACGCCGGCCGGAGAATCGTGGGATGAATGGTTCGACGGGA
ACAACGTCAGCGCCGATTTTATGGATAACCGGGAACAACCCTCTGTGCAGGAACGGGAATCATTCTGA