Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4377569..4378350 Replicon chromosome
Accession NZ_CP084194
Organism Salmonella sp. A39

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag LDO68_RS21490 Protein ID WP_000626099.1
Coordinates 4377569..4378060 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LDO68_RS21495 Protein ID WP_001110452.1
Coordinates 4378057..4378350 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO68_RS21455 (4373564) 4373564..4374139 + 576 WP_001188509.1 transcriptional regulator -
LDO68_RS21465 (4374410) 4374410..4374487 - 78 Protein_4194 helix-turn-helix domain-containing protein -
LDO68_RS21470 (4374578) 4374578..4374910 - 333 WP_001165471.1 MerR family transcriptional regulator -
LDO68_RS21475 (4374982) 4374982..4375359 + 378 WP_000916345.1 EthD family reductase -
LDO68_RS21480 (4376392) 4376392..4376466 + 75 Protein_4197 porin family protein -
LDO68_RS21485 (4376569) 4376569..4377321 + 753 WP_000842434.1 non-specific acid phosphatase -
LDO68_RS21490 (4377569) 4377569..4378060 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
LDO68_RS21495 (4378057) 4378057..4378350 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LDO68_RS21500 (4378667) 4378667..4378888 + 222 WP_001576552.1 hypothetical protein -
LDO68_RS21505 (4379153) 4379153..4380028 + 876 WP_000921674.1 AraC family transcriptional regulator -
LDO68_RS21510 (4380025) 4380025..4380312 + 288 WP_001269916.1 transcriptional regulator RtsB -
LDO68_RS21515 (4380335) 4380335..4380550 + 216 WP_001595136.1 hypothetical protein -
LDO68_RS21520 (4380558) 4380558..4380827 + 270 WP_010989096.1 hypothetical protein -
LDO68_RS21525 (4381121) 4381121..4382026 - 906 Protein_4206 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T218176 WP_000626099.1 NZ_CP084194:c4378060-4377569 [Salmonella sp. A39]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T218176 NZ_CP115669:c71453-71172 [Pseudomonas sp. PSE14]
ATGAGCCTGAAGTGGACGCACAAGGCGGCGGGCGACCTGGACGCCATCTATGACCACTACGTCGTGCTGATCGGCCCGGA
GAAGGCGCTGCGGGCCATCCAGGACATCGTCGAGCAGGTTCGTCCGCTGGCGAACCTCGACCTGAGCAGCAGCGGCGTGC
CCAGCGAAGTGCCCGGCGTCCGGGAATTGCCGGTGGAGCGCTGGCCCTACCAGGCCGCCTACCGGGTAAAGGGGCGTTCT
GTACAGATTTTGCGCATCGACCGTGTGGATAACTCGGGGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT218176 WP_001110452.1 NZ_CP084194:c4378350-4378057 [Salmonella sp. A39]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT218176 NZ_CP115669:c71677-71450 [Pseudomonas sp. PSE14]
GTGACCACCGTTGTCTCCTTCCGCGCCGATGACGCCCTCGTCCAGGCCCTGGACCAGTTGGCCCGCGCCACCCACCGGGA
CCGGCCGTATCACCTGCGCCAGGCCCTGGCGCAGTACCTGGAGCGCCAGAGCTGGCACGTCGCGGCCATCGATGAAGGCG
TGGCAGACGCCGATGCCGGCCACCTGCTGGAACACGCCGTCATCGAAGCCAAGTGGGGGCTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References