Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2449961..2450483 Replicon chromosome
Accession NZ_CP084194
Organism Salmonella sp. A39

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag LDO68_RS12045 Protein ID WP_000221343.1
Coordinates 2450199..2450483 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LDO68_RS12040 Protein ID WP_000885424.1
Coordinates 2449961..2450209 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO68_RS12015 (2445177) 2445177..2446643 + 1467 WP_000987828.1 hypothetical protein -
LDO68_RS12020 (2447451) 2447451..2448165 + 715 Protein_2350 helix-turn-helix domain-containing protein -
LDO68_RS12025 (2448221) 2448221..2449129 - 909 WP_010989018.1 hypothetical protein -
LDO68_RS12030 (2449272) 2449272..2449604 - 333 WP_000253154.1 DUF1493 family protein -
LDO68_RS12035 (2449594) 2449594..2449809 - 216 WP_000206207.1 hypothetical protein -
LDO68_RS12040 (2449961) 2449961..2450209 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LDO68_RS12045 (2450199) 2450199..2450483 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO68_RS12050 (2450654) 2450654..2451043 + 390 WP_000194089.1 RidA family protein -
LDO68_RS12055 (2451095) 2451095..2452174 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LDO68_RS12060 (2452367) 2452367..2452855 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
LDO68_RS12065 (2452900) 2452900..2454408 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2445180..2457265 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T218168 WP_000221343.1 NZ_CP084194:2450199-2450483 [Salmonella sp. A39]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T218168 NZ_CP115665:c1375704-1375390 [Pseudomonas putida]
ATGATCTTCATCGAGACCCCAGTATTCACCTCCGATCTCAAGGAGCACCTGGATGATGAAGAATACCGGGCTTTGCAGGC
CTATCTGGCCGAGCATCCCGAAGCCGGTTCTCTCCTGGAGGAAACCGGCGGCCTCAGAAAGATCCGCTGGGCAGCCAAGG
GCAAGGGCAAGAGTGGGGGTGTACGAGTGATCTACTACCACGTCACTGCAGCCCACCAGATCCGTATGATTCTGATCTAT
CGCAAGGGCATCGTGGATACCTTGACAAGCAGTCAGAAAGCGCAGCTTCGCGCACTAAACAAAGGGTGGAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT218168 WP_000885424.1 NZ_CP084194:2449961-2450209 [Salmonella sp. A39]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT218168 NZ_CP115665:c1375390-1375103 [Pseudomonas putida]
ATGGAAAAGCATCTCTTCGATCGTCTTGTGGAAAGCATGACTCAGATGGATGAGATCGATCGCGGTGAGCGTCAGCCCTC
GCGTGAGTTCCACGTAGACGCACTTCAAGTCAAAAAGATTCGTCAAGCCACTGGCCTTTCCCAGGCTGCGTTTGCCAAAC
GTATCGATGTCGCAGTAGGAACTCTACGGAATTGGGAACAGGGCCGTCGCGAACCTGAAGGACCAGCTCGTGCCTTGCTT
CGAGCGATTCATAACGATCCCGAACATGTACTTGCGGCCTTGAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References