Detailed information of TA system TA021816

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 3483858..3484961
• Replicon: chromosome
• Accession: NC_008700
• Organism: Shewanella amazonensis SB2B

Toxin (Protein)

• Gene name: -
• Uniprot ID: A1S9S6
• Locus tag: SAMA_RS15300
• Protein ID: WP_011761038.1
• Coordinates: 3483858..3484598 (-)
• Length: 247 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A1S9S7
• Locus tag: SAMA_RS15305
• Protein ID: WP_011761039.1
• Coordinates: 3484599..3484961 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAMA_RS15275	3480377..3480796	+	420	WP_011761033.1	CBS domain-containing protein	-
SAMA_RS15280	3480845..3481534	-	690	WP_011761034.1	LrgB family protein	-
SAMA_RS15285	3481534..3481965	-	432	WP_011761035.1	CidA/LrgA family protein	-
SAMA_RS15290	3482069..3482959	+	891	WP_011761036.1	LysR family transcriptional regulator	-
SAMA_RS15295	3483023..3483838	-	816	WP_011761037.1	hypothetical protein	-
SAMA_RS15300	3483858..3484598	-	741	WP_011761038.1	RES family NAD+ phosphorylase	Toxin
SAMA_RS15305	3484599..3484961	-	363	WP_011761039.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
SAMA_RS15310	3485204..3485857	+	654	WP_011761040.1	oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB	-
SAMA_RS15315	3485997..3486647	+	651	WP_011761041.1	DnaJ domain-containing protein	-
SAMA_RS15320	3486807..3487553	+	747	WP_011761042.1	thiol:disulfide interchange protein DsbA/DsbL	-
SAMA_RS15325	3487928..3489265	+	1338	WP_011761043.1	Na+/H+ antiporter NhaC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (54-202)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (5-65)

Sequences

Toxin

Protein

• Length: 247 a.a.
• Molecular weight: 28089.90 Da
• Isoelectric Point: 4.6178

>T21816 WP_011761038.1 NC_008700:c3484598-3483858 [Shewanella amazonensis SB2B]
MDLLSIPEDCIDLPYEGSCYRLVESQEEVATLSLVDNFDEQMLLESLLDGAKPPYREGTAHLHYLLKTPFRYPPLKHGSR
FGTRLMPSFFYGSESAQTCLTEVAYYRFIFLQDMAVPYEGVLHSEYMMFRVLLSATRCADLTQISDDALQQQLTHGEDYR
FTQALGQQLIERDCQLIRSFSAREPGGVNLAVADPGVMASAPLEQSYWICQLEPARLAFTERGRGNLPRYYEVEAFFREG
RLPRPA

Nucleotide

• Length: 741 bp

>T21816 NC_008700:c3484598-3483858 [Shewanella amazonensis SB2B]
ATGGACTTACTTTCAATCCCCGAAGACTGTATCGATTTGCCCTATGAGGGTAGTTGCTACCGGTTGGTGGAGTCTCAGGA
AGAGGTGGCTACCCTGAGCCTGGTGGATAATTTTGACGAGCAAATGCTGCTGGAAAGCCTGCTGGATGGCGCCAAGCCCC
CATACAGGGAAGGCACAGCCCATTTGCACTATCTGCTGAAAACCCCTTTTCGTTACCCGCCGTTAAAACATGGTTCGCGT
TTTGGTACCCGACTGATGCCCAGCTTTTTTTATGGCAGTGAGTCGGCCCAAACCTGTTTGACCGAAGTGGCTTATTACCG
CTTTATCTTTTTGCAGGATATGGCAGTGCCTTATGAGGGCGTGCTGCACTCGGAGTACATGATGTTCAGGGTGTTGCTCA
GTGCAACGCGCTGCGCCGACCTCACCCAAATTTCCGATGACGCTCTGCAGCAACAGCTTACCCACGGCGAAGACTACCGT
TTTACTCAGGCGCTGGGGCAGCAACTGATTGAACGTGACTGCCAGCTTATTCGCAGCTTCTCGGCCCGTGAGCCGGGAGG
GGTTAACCTCGCGGTGGCAGATCCCGGTGTGATGGCGTCCGCACCTTTGGAACAGAGTTACTGGATTTGTCAGCTGGAGC
CTGCCAGACTCGCTTTTACCGAACGCGGCCGGGGGAATCTGCCGCGATACTATGAAGTGGAAGCATTTTTTCGCGAAGGA
CGCCTGCCGCGTCCAGCCTGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 12938.85 Da
• Isoelectric Point: 10.2283

>AT21816 WP_011761039.1 NC_008700:c3484961-3484599 [Shewanella amazonensis SB2B]
MSAIAKPTASGVLFKAFTNACQALELTNAEASHIIGVNPSTLSRNAANGFKPESKQGELQLQLVRLYRSLYALAGGQQDF
MRHWLNSPNHALGGTPRELVKSVVGLVSVNQYLDAMRGKV

Nucleotide

• Length: 363 bp

>AT21816 NC_008700:c3484961-3484599 [Shewanella amazonensis SB2B]
ATGTCTGCTATCGCCAAACCCACAGCATCCGGGGTCTTGTTCAAGGCCTTTACCAATGCCTGTCAGGCGCTGGAACTGAC
CAACGCCGAGGCGAGTCATATCATAGGGGTCAATCCCAGTACCCTGAGTCGCAATGCTGCCAATGGCTTTAAACCCGAGT
CAAAGCAGGGGGAGCTGCAGTTGCAGCTGGTGCGTTTGTATCGCTCGCTGTACGCCCTCGCGGGTGGACAGCAGGACTTT
ATGCGCCATTGGCTCAACAGCCCCAATCATGCACTTGGGGGTACACCCCGGGAGCTGGTCAAGTCTGTGGTGGGCCTGGT
CAGTGTGAATCAATACCTCGATGCCATGCGTGGCAAGGTGTAA

Structures

Toxin

• AlphaFold DB: A1S9S6

Antitoxin

• AlphaFold DB: A1S9S7