Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 839407..840067 Replicon chromosome
Accession NZ_CP084194
Organism Salmonella sp. A39

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LDO68_RS04040 Protein ID WP_000244756.1
Coordinates 839654..840067 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LDO68_RS04035 Protein ID WP_000351186.1
Coordinates 839407..839673 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO68_RS04015 (835335) 835335..836768 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
LDO68_RS04020 (836927) 836927..837238 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LDO68_RS04025 (837402) 837402..838061 + 660 WP_000250289.1 hemolysin III family protein -
LDO68_RS04030 (838177) 838177..839157 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
LDO68_RS04035 (839407) 839407..839673 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LDO68_RS04040 (839654) 839654..840067 + 414 WP_000244756.1 protein YgfX Toxin
LDO68_RS04045 (840120) 840120..840641 - 522 WP_001055885.1 flavodoxin FldB -
LDO68_RS04050 (840754) 840754..841650 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LDO68_RS04055 (841674) 841674..842387 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LDO68_RS04060 (842393) 842393..844126 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T218157 WP_000244756.1 NZ_CP084194:839654-840067 [Salmonella sp. A39]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T218157 NZ_CP115661:2764222-2764515 [Pseudomonas putida]
GTGCCACGACTGATCGTCACTGAAGGCGCGGCGAAGGGCCTGGAGCGTTGCCGGCGATTTCTCTCCGATAAAGATCCGCA
GGTCGCACGCCGTGCTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCTTTTC
CAGATCTGCCAGAGCTGCGTGAGCTCATCATCGAGTTTGGTGACTCAGGTTACGTCGCGCTGTACCGCTATGAGCGCGCA
GATGACACCGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT218157 WP_000351186.1 NZ_CP084194:839407-839673 [Salmonella sp. A39]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT218157 NZ_CP115661:2763962-2764234 [Pseudomonas putida]
ATGGCCACTTCCATCAAAATTGACGACGATCTGAAAGGTCGCATTCAGCATTTGGCTTGTTTGCGCCAGCGCTCATCTCA
CTGGATCATGCGTGAGGCGATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTCAAACAAGAAGCGCTGGCAT
CTTGGGCTGCATACCAGGAAACCGGCCAGCACTTGACCGGCCAGGAGGCTCGCACCTGGCTTGGTAGTTGGGGTACAGAT
GCTGAGGCAGAGTTACCCAAGTGCCACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References