Detailed information of TA system TA218151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4878534..4880122
• Replicon: chromosome
• Accession: NZ_CP084168
• Organism: Klebsiella pneumoniae strain B17602

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A9J6RYF8
• Locus tag: LDH50_RS23425
• Protein ID: WP_004892016.1
• Coordinates: 4878800..4880122 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LDH50_RS23420
• Protein ID: WP_004176198.1
• Coordinates: 4878534..4878800 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDH50_RS23395 (LDH50_23395)	4873686..4874609	+	924	WP_004892028.1	LysR family hpxDE operon transcriptional regulator HpxR	-
LDH50_RS23400 (LDH50_23400)	4874590..4875744	-	1155	WP_004892025.1	FAD-dependent urate hydroxylase HpxO	-
LDH50_RS23405 (LDH50_23405)	4876089..4877468	+	1380	WP_004176204.1	nucleobase:cation symporter-2 family protein	-
LDH50_RS23410 (LDH50_23410)	4877446..4877946	+	501	WP_004892023.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LDH50_RS23415 (LDH50_23415)	4877943..4878269	+	327	WP_004892019.1	hydroxyisourate hydrolase	-
LDH50_RS23420 (LDH50_23420)	4878534..4878800	+	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LDH50_RS23425 (LDH50_23425)	4878800..4880122	+	1323	WP_004892016.1	type II toxin-antitoxin system HipA family toxin	Toxin
LDH50_RS23430 (LDH50_23430)	4880139..4881431	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LDH50_RS23435 (LDH50_23435)	4881573..4882577	-	1005	WP_004892012.1	fimbrial protein	-
LDH50_RS23440 (LDH50_23440)	4882565..4885066	-	2502	WP_004892009.1	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	iroE / mgtC	4843052..5068765	225713

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49141.44 Da
• Isoelectric Point: 7.5357

>T218151 WP_004892016.1 NZ_CP084168:4878800-4880122 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T218151 NZ_CP115659:3914510-3914728 [Kosakonia oryzendophytica]
ATGTCCGAAAAACCATTAACAAAAATTGATTATTTGATGCGGTTACGGCGTTGTCAGACAATTGATACATTAGAACGCGT
AATTGAAAAAAATAAATACGAACTTTCAGATGATGAACTTGCGGTGTTTTATTCTGCAGCCGATCACCGGCTGGCAGAGC
TGACTATGAATAAGCTTTATGACAAAATCCCCTCCTCCGTGTGGAAATTTGTTCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT218151 WP_004176198.1 NZ_CP084168:4878534-4878800 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT218151 NZ_CP115659:3914112-3914486 [Kosakonia oryzendophytica]
ATGGACGAATACTCGCCGAAAAGGCATGATATCGCACAGCTCAAATTTCTCTGCGAAACTTTGTACCATGATTGCCTCGC
TAATCTCGAAGAGAGCCATCATGGCTGGGTTAACGATCCTACTTCAGCAATCAATCTGCAGCTAAACGAGCTGATCGAGC
ACATCGCAACCTTCGCGCTCAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGCACAGATAGACGAATACCTT
GATGATACGTTTATGTTGTTTAGCAGCTATGGCATAAATACACAAGACTTACAGAAATGGCGTAAAACAGGCAACAAACT
GTTCCGCTGCTTCGTCAATGTGAGCAAGGCTAATCCTGTTAGTCACTCTTGTTAA