Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3547541..3548160 Replicon chromosome
Accession NZ_CP084168
Organism Klebsiella pneumoniae strain B17602

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LDH50_RS17090 Protein ID WP_002892050.1
Coordinates 3547541..3547759 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LDH50_RS17095 Protein ID WP_002892066.1
Coordinates 3547786..3548160 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH50_RS17055 (LDH50_17055) 3543588..3543851 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
LDH50_RS17060 (LDH50_17060) 3543851..3543991 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LDH50_RS17065 (LDH50_17065) 3543988..3544686 - 699 WP_004893822.1 GNAT family protein -
LDH50_RS17070 (LDH50_17070) 3544787..3546238 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LDH50_RS17075 (LDH50_17075) 3546213..3546683 - 471 WP_002892026.1 YlaC family protein -
LDH50_RS17080 (LDH50_17080) 3546704..3546844 + 141 WP_032409038.1 hypothetical protein -
LDH50_RS17085 (LDH50_17085) 3546816..3547382 - 567 WP_002892030.1 maltose O-acetyltransferase -
LDH50_RS17090 (LDH50_17090) 3547541..3547759 - 219 WP_002892050.1 HHA domain-containing protein Toxin
LDH50_RS17095 (LDH50_17095) 3547786..3548160 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LDH50_RS17100 (LDH50_17100) 3548646..3551792 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LDH50_RS17105 (LDH50_17105) 3551815..3553008 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T218149 WP_002892050.1 NZ_CP084168:c3547759-3547541 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T218149 NZ_CP115659:3347383-3347859 [Kosakonia oryzendophytica]
TTGATTTTCTATCGCCTTGTGACGCACCGCTACGCCAGCGAAGCCTGGACTGGCAGTGGTGCAAACCTCTTTGGTGGTAG
ATGGAATCATAAAGGTCACCCGGCTGTTTACGTCGCGTCGTCCATTTCACTGGCGGCGCTGGAAATGCTGGTACATGTGC
ACAGCGACACTGTTCTCACCCAGTACGGACTGTTCAGTATTGAGATACCCGATAACGATATTGAATACCTTGATAAACAA
TGGTTACCACCCGACTGGCAGGAAAACCCCGCCCCTCTCTCAACCATGGATCTCGGTACCGCATGGCTCGAAGCCAACAG
TGGCGTTGCCCTGGTTCTGCCTTCCTGCGTGGTTCCACTCGAGAACAACGCTATGCTGAACCCACAACACCCGACTTTCA
GCCAGTTGCTAAAAACAGTCAAAGCGCTTCCCTTTTCTTTTGATGCCCGCCTGGTTAATCAAACCACGTTGCGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT218149 WP_002892066.1 NZ_CP084168:c3548160-3547786 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT218149 NZ_CP115659:3346943-3347386 [Kosakonia oryzendophytica]
ATGAGAACCTGGAGCCCGGATCAAAAACCGGCTGAAAATGCGCTCTGGCGCTTTGCCGGTTTCCCCGCAAACAGAGGACT
TAAGCTCGTTCAGATGCTAAATGAAGGTTTGCCCGTCAGCATCCTCGATAATATCCATGAATGGACGGAAATGTCCCTTT
CCGATATTTTGCGCGTAACAGGAATTAATGAACGCAACGTCGCCCGCCGTAAAAGCACCGGTCGGACATTAACACCGGAA
GAGAGCGAACGCATTGCGCGTCTGGTCAGAGTGGTCGATGCTGCGGTGCAGTTTTTCGGCAACAAAAAGATGGCATATGA
CTGGTTGCAAGCACCCGTTCGCGGTTTGGGCAACGTTGCGCCGATCTCGTTAATCGCCACTGAAAGCGGCGCGCTGGAAG
TAACCGATCTGATTGGCCGTCTGGAACATGGGGTGTTTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References