Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2812310..2812826 Replicon chromosome
Accession NZ_CP084168
Organism Klebsiella pneumoniae strain B17602

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag LDH50_RS13595 Protein ID WP_004894697.1
Coordinates 2812542..2812826 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LDH50_RS13590 Protein ID WP_002886901.1
Coordinates 2812310..2812552 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH50_RS13575 (LDH50_13575) 2808338..2809078 + 741 WP_002886899.1 KDGP aldolase family protein -
LDH50_RS13580 (LDH50_13580) 2809145..2810299 + 1155 WP_004178372.1 lactonase family protein -
LDH50_RS13585 (LDH50_13585) 2810322..2812232 + 1911 WP_023325426.1 PRD domain-containing protein -
LDH50_RS13590 (LDH50_13590) 2812310..2812552 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LDH50_RS13595 (LDH50_13595) 2812542..2812826 + 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDH50_RS13600 (LDH50_13600) 2812830..2813294 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LDH50_RS13605 (LDH50_13605) 2813623..2815761 - 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
LDH50_RS13610 (LDH50_13610) 2816119..2816862 - 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
LDH50_RS13615 (LDH50_13615) 2816865..2817038 - 174 WP_002886906.1 hypothetical protein -
LDH50_RS13620 (LDH50_13620) 2817168..2817431 + 264 WP_031280360.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T218147 WP_004894697.1 NZ_CP084168:2812542-2812826 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T218147 NZ_CP115659:866516-866932 [Kosakonia oryzendophytica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCGCAATGGCTCTCTTTACTGCTCCATGGTCTGGTGGCGGC
ACTGATATTGCTGATGCCATGGCCATTGAGCTATACGCCATTGTGGCTGTTATTGCTATCGCTGGTGGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATCAATGCCTGCCATGGTGAGATCAAACTGCTGATGGAGTCACGTCTACGCTGGCAGGGCGTT
GAGTGGAATATTGTCGGTGCGCCGTGGATGTTACGCAGCGGTATGATGCTGCGGTTACGCCGTGAAGAAGACGGACGACG
CCAACATTTGTGGCTGGCGGCGGACAGCATGGATGCACAGGAGTGGCGCGATCTGCGCCGGATGCTCTCTCAAAAGTCGG
CGCAGGGGCTGCATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT218147 WP_002886901.1 NZ_CP084168:2812310-2812552 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT218147 NZ_CP115659:866269-866535 [Kosakonia oryzendophytica]
ATGGATATTAATAACAAAGCCCGTATCCACTGGGCGTGCCGCCGTGGAATGCGCGAACTCGATATCTCCATCATGCCTTT
TTTTGAACATGAGTACGACACGCTGAGCGATGACGACAAGCATCTGTTTGTGCGCCTGCTGGAAAGTGATGACCCGGACT
TATTTAACTGGCTGATGAATCATGGCAAACCTCAGGATGCGGGGTTGCAGAGAATGGTGCAGTTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References