Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1479458..1480115 Replicon chromosome
Accession NZ_CP084168
Organism Klebsiella pneumoniae strain B17602

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LDH50_RS07085 Protein ID WP_002916310.1
Coordinates 1479458..1479868 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LDH50_RS07090 Protein ID WP_002916312.1
Coordinates 1479849..1480115 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH50_RS07065 (LDH50_07065) 1475458..1477191 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
LDH50_RS07070 (LDH50_07070) 1477197..1477910 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LDH50_RS07075 (LDH50_07075) 1477933..1478829 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LDH50_RS07080 (LDH50_07080) 1478930..1479451 + 522 WP_004144730.1 flavodoxin FldB -
LDH50_RS07085 (LDH50_07085) 1479458..1479868 - 411 WP_002916310.1 protein YgfX Toxin
LDH50_RS07090 (LDH50_07090) 1479849..1480115 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LDH50_RS07095 (LDH50_07095) 1480361..1481344 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LDH50_RS07100 (LDH50_07100) 1481495..1482154 - 660 WP_004889817.1 hemolysin III family protein -
LDH50_RS07105 (LDH50_07105) 1482318..1482629 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LDH50_RS07110 (LDH50_07110) 1482679..1483407 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LDH50_RS07115 (LDH50_07115) 1483526..1484959 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T218142 WP_002916310.1 NZ_CP084168:c1479868-1479458 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T218142 NZ_CP115645:549578-549967 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTACTTTGAAGATCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT218142 WP_002916312.1 NZ_CP084168:c1480115-1479849 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT218142 NZ_CP115645:549314-549571 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References