Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2852274..2852851 Replicon chromosome
Accession NC_008699
Organism Nocardioides sp. JS614

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NOCA_RS15060 Protein ID WP_140403835.1
Coordinates 2852274..2852474 (-) Length 67 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NOCA_RS15065 Protein ID WP_011756124.1
Coordinates 2852567..2852851 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOCA_RS27830 2847355..2847510 - 156 WP_172419816.1 hypothetical protein -
NOCA_RS15040 2847756..2848508 + 753 WP_011756118.1 DinB family protein -
NOCA_RS15045 2848679..2849257 + 579 WP_083768166.1 helix-turn-helix transcriptional regulator -
NOCA_RS15050 2849268..2849678 + 411 WP_011756121.1 VOC family protein -
NOCA_RS15055 2849706..2852093 + 2388 WP_011756122.1 excinuclease ABC subunit UvrA -
NOCA_RS15060 2852274..2852474 - 201 WP_140403835.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOCA_RS15065 2852567..2852851 - 285 WP_011756124.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NOCA_RS15070 2852923..2853420 + 498 WP_011756125.1 VOC family protein -
NOCA_RS15075 2853417..2854313 - 897 WP_011756126.1 LLM class F420-dependent oxidoreductase -
NOCA_RS15080 2854324..2855061 - 738 WP_011756127.1 M50 family metallopeptidase -
NOCA_RS15085 2855099..2855341 + 243 WP_140403834.1 hypothetical protein -
NOCA_RS15090 2855338..2855775 + 438 WP_011756129.1 hypothetical protein -
NOCA_RS15095 2855857..2856528 + 672 WP_011756130.1 lysoplasmalogenase -
NOCA_RS15100 2856539..2857375 + 837 WP_011756131.1 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(16-62)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7815.23 Da        Isoelectric Point: 11.9551

>T21814 WP_140403835.1 NC_008699:c2852474-2852274 [Nocardioides sp. JS614]
MAAFEFIRGPLREAPRRVGKPLLEPLTPLWSARRGEYRILYRILDRRLVIAVVTIAHRRDAYGRRE

Download         Length: 201 bp

>T21814 NC_008699:c2852474-2852274 [Nocardioides sp. JS614]
ATGGCGGCGTTCGAGTTCATCCGCGGGCCGCTGCGCGAAGCGCCCCGCCGCGTGGGCAAACCCCTCCTCGAGCCGCTCAC
GCCGCTGTGGTCGGCGCGGAGGGGCGAGTACCGCATCCTGTATCGCATCCTCGACCGGCGCCTGGTGATCGCGGTGGTCA
CGATCGCGCACCGGCGAGACGCCTACGGGCGCCGGGAGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10124.43 Da        Isoelectric Point: 4.4179

>AT21814 WP_011756124.1 NC_008699:c2852851-2852567 [Nocardioides sp. JS614]
MTTLSLAAARASLSKLVEAAVTTHERFEVTRNGDRVAVLLSAEDYDALLETVDVLSRADEVEALRAGLADLEAGEVSTLD
EVRVAMQRRGRLPA

Download         Length: 285 bp

>AT21814 NC_008699:c2852851-2852567 [Nocardioides sp. JS614]
ATGACGACGCTCTCGCTTGCTGCCGCGCGGGCCAGCCTGTCCAAGCTCGTGGAGGCGGCGGTCACCACGCACGAGCGGTT
CGAGGTGACGCGGAACGGCGATCGGGTCGCCGTGCTGCTCAGCGCCGAGGACTATGACGCGCTGCTCGAGACCGTCGACG
TCCTCAGCCGCGCCGATGAGGTCGAGGCCCTGCGCGCGGGGCTGGCGGACCTCGAGGCCGGGGAGGTCTCGACGCTCGAC
GAGGTCCGCGTCGCGATGCAGCGACGCGGGCGACTGCCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References