Detailed information of TA system TA021814

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2852274..2852851
• Replicon: chromosome
• Accession: NC_008699
• Organism: Nocardioides sp. JS614

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: NOCA_RS15060
• Protein ID: WP_140403835.1
• Coordinates: 2852274..2852474 (-)
• Length: 67 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: NOCA_RS15065
• Protein ID: WP_011756124.1
• Coordinates: 2852567..2852851 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NOCA_RS27830	2847355..2847510	-	156	WP_172419816.1	hypothetical protein	-
NOCA_RS15040	2847756..2848508	+	753	WP_011756118.1	DinB family protein	-
NOCA_RS15045	2848679..2849257	+	579	WP_083768166.1	helix-turn-helix transcriptional regulator	-
NOCA_RS15050	2849268..2849678	+	411	WP_011756121.1	VOC family protein	-
NOCA_RS15055	2849706..2852093	+	2388	WP_011756122.1	excinuclease ABC subunit UvrA	-
NOCA_RS15060	2852274..2852474	-	201	WP_140403835.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NOCA_RS15065	2852567..2852851	-	285	WP_011756124.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
NOCA_RS15070	2852923..2853420	+	498	WP_011756125.1	VOC family protein	-
NOCA_RS15075	2853417..2854313	-	897	WP_011756126.1	LLM class F420-dependent oxidoreductase	-
NOCA_RS15080	2854324..2855061	-	738	WP_011756127.1	M50 family metallopeptidase	-
NOCA_RS15085	2855099..2855341	+	243	WP_140403834.1	hypothetical protein	-
NOCA_RS15090	2855338..2855775	+	438	WP_011756129.1	hypothetical protein	-
NOCA_RS15095	2855857..2856528	+	672	WP_011756130.1	lysoplasmalogenase	-
NOCA_RS15100	2856539..2857375	+	837	WP_011756131.1	aldo/keto reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (16-62)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 67 a.a.
• Molecular weight: 7815.23 Da
• Isoelectric Point: 11.9551

>T21814 WP_140403835.1 NC_008699:c2852474-2852274 [Nocardioides sp. JS614]
MAAFEFIRGPLREAPRRVGKPLLEPLTPLWSARRGEYRILYRILDRRLVIAVVTIAHRRDAYGRRE

Nucleotide

• Length: 201 bp

>T21814 NC_008699:c2852474-2852274 [Nocardioides sp. JS614]
ATGGCGGCGTTCGAGTTCATCCGCGGGCCGCTGCGCGAAGCGCCCCGCCGCGTGGGCAAACCCCTCCTCGAGCCGCTCAC
GCCGCTGTGGTCGGCGCGGAGGGGCGAGTACCGCATCCTGTATCGCATCCTCGACCGGCGCCTGGTGATCGCGGTGGTCA
CGATCGCGCACCGGCGAGACGCCTACGGGCGCCGGGAGTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10124.43 Da
• Isoelectric Point: 4.4179

>AT21814 WP_011756124.1 NC_008699:c2852851-2852567 [Nocardioides sp. JS614]
MTTLSLAAARASLSKLVEAAVTTHERFEVTRNGDRVAVLLSAEDYDALLETVDVLSRADEVEALRAGLADLEAGEVSTLD
EVRVAMQRRGRLPA

Nucleotide

• Length: 285 bp

>AT21814 NC_008699:c2852851-2852567 [Nocardioides sp. JS614]
ATGACGACGCTCTCGCTTGCTGCCGCGCGGGCCAGCCTGTCCAAGCTCGTGGAGGCGGCGGTCACCACGCACGAGCGGTT
CGAGGTGACGCGGAACGGCGATCGGGTCGCCGTGCTGCTCAGCGCCGAGGACTATGACGCGCTGCTCGAGACCGTCGACG
TCCTCAGCCGCGCCGATGAGGTCGAGGCCCTGCGCGCGGGGCTGGCGGACCTCGAGGCCGGGGAGGTCTCGACGCTCGAC
GAGGTCCGCGTCGCGATGCAGCGACGCGGGCGACTGCCCGCGTGA