Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 266860..267461 Replicon plasmid unnamed
Accession NZ_CP084164
Organism Pasteurella multocida strain s4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LCY73_RS01475 Protein ID WP_078819687.1
Coordinates 267147..267461 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LCY73_RS01470 Protein ID WP_078819686.1
Coordinates 266860..267150 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCY73_RS01435 (LCY73_01435) 261886..262101 - 216 WP_075271368.1 hypothetical protein -
LCY73_RS01440 (LCY73_01440) 262098..262781 - 684 WP_014390721.1 phage antirepressor KilAC domain-containing protein -
LCY73_RS01445 (LCY73_01445) 262839..263288 - 450 WP_099821840.1 YmfL family putative regulatory protein -
LCY73_RS01450 (LCY73_01450) 263337..263537 - 201 WP_099821841.1 YdaS family helix-turn-helix protein -
LCY73_RS01455 (LCY73_01455) 263662..264345 + 684 WP_099821842.1 S24 family peptidase -
LCY73_RS01460 (LCY73_01460) 264556..266400 + 1845 WP_071523830.1 DEAD/DEAH box helicase family protein -
LCY73_RS01465 (LCY73_01465) 266430..266834 + 405 WP_146024473.1 hypothetical protein -
LCY73_RS01470 (LCY73_01470) 266860..267150 - 291 WP_078819686.1 putative addiction module antidote protein Antitoxin
LCY73_RS01475 (LCY73_01475) 267147..267461 - 315 WP_078819687.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCY73_RS01480 (LCY73_01480) 267767..267934 - 168 WP_005756653.1 DUF1508 domain-containing protein -
LCY73_RS01485 (LCY73_01485) 267947..268156 + 210 WP_005756656.1 hypothetical protein -
LCY73_RS01490 (LCY73_01490) 268398..268628 + 231 WP_078737821.1 hypothetical protein -
LCY73_RS01495 (LCY73_01495) 268641..268811 + 171 WP_225529669.1 hypothetical protein -
LCY73_RS01500 (LCY73_01500) 268792..268986 - 195 WP_014391459.1 hypothetical protein -
LCY73_RS01505 (LCY73_01505) 269350..269694 + 345 Protein_292 Bro-N domain-containing protein -
LCY73_RS01510 (LCY73_01510) 269968..270624 + 657 WP_225529682.1 KilA-N domain-containing protein -
LCY73_RS01515 (LCY73_01515) 270686..270916 - 231 WP_223251317.1 hypothetical protein -
LCY73_RS01520 (LCY73_01520) 271064..271363 + 300 WP_078802174.1 hypothetical protein -
LCY73_RS01525 (LCY73_01525) 271335..271571 + 237 WP_075271355.1 hypothetical protein -
LCY73_RS01530 (LCY73_01530) 271584..271871 + 288 WP_014391452.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - orfM 1..274750 274750


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11763.65 Da        Isoelectric Point: 9.5553

>T218133 WP_078819687.1 NZ_CP084164:c267461-267147 [Pasteurella multocida]
MLDIIETTVFNKWLKELKDLSAKAAILARISRAKSGNFGDHKSVGDGLYEMRIMKGAGYRVYYAQYKDVTYLLICGGDKS
TQKADIAKAKALWEEIKQKEEINV

Download         Length: 315 bp

>T218133 NZ_CP115629:449419-449808 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10574.22 Da        Isoelectric Point: 5.7134

>AT218133 WP_078819686.1 NZ_CP084164:c267150-266860 [Pasteurella multocida]
MSKKVELKPFDIAEYLDSEEMIAAYLSEILETGDTNEFISALGDVARARGMTELAAKTGLGRESLYKTLSHGSKPRFDTI
MKITQALGIKLVPTHI

Download         Length: 291 bp

>AT218133 NZ_CP115629:449155-449412 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References