Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 188285..188800 Replicon chromosome
Accession NZ_CP084109
Organism Micrococcus luteus strain anQ-m1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LCP49_RS00835 Protein ID WP_134416751.1
Coordinates 188285..188539 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LCP49_RS00840 Protein ID WP_134416753.1
Coordinates 188540..188800 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCP49_RS00805 183791..185197 + 1407 WP_163721243.1 Dyp-type peroxidase -
LCP49_RS00810 185194..185583 + 390 WP_163721241.1 hypothetical protein -
LCP49_RS00815 185615..186352 + 738 WP_205521335.1 histidine phosphatase family protein -
LCP49_RS00820 186349..186891 + 543 WP_134416745.1 DUF3090 domain-containing protein -
LCP49_RS00825 186891..187673 + 783 WP_134416747.1 SCO1664 family protein -
LCP49_RS00830 187717..188283 - 567 WP_134416749.1 mismatch-specific DNA-glycosylase -
LCP49_RS00835 188285..188539 - 255 WP_134416751.1 Txe/YoeB family addiction module toxin Toxin
LCP49_RS00840 188540..188800 - 261 WP_134416753.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LCP49_RS00845 188928..190271 + 1344 WP_044658726.1 IS256-like element ISMlu11 family transposase -
LCP49_RS00850 190446..190589 + 144 WP_225348956.1 hypothetical protein -
LCP49_RS00855 190586..191527 + 942 WP_242821290.1 hypothetical protein -
LCP49_RS00860 191557..192711 + 1155 WP_225348580.1 glycerate kinase -
LCP49_RS00865 192733..193122 + 390 Protein_168 phosphatidylinositol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 188922..190271 1349


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10024.39 Da        Isoelectric Point: 7.3149

>T218131 WP_134416751.1 NZ_CP084109:c188539-188285 [Micrococcus luteus]
VRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFDGIGKPEQLKYGAPGAWSRRITEEHRLVYLVDGEDLIILQV
RYHY

Download         Length: 255 bp

>T218131 NZ_CP115627:c27427-27068 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGTCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTATGGAGATAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9639.82 Da        Isoelectric Point: 4.8483

>AT218131 WP_134416753.1 NZ_CP084109:c188800-188540 [Micrococcus luteus]
MSISASEARKTLFPLIERVNADREVVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RMDGDA

Download         Length: 261 bp

>AT218131 NZ_CP115627:c27068-26769 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References