218125

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2111051..2111565 Replicon chromosome
Accession NZ_CP084107
Organism Staphylococcus aureus strain CC49/ST49-MSSA

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LB316_RS10385 Protein ID WP_000581792.1
Coordinates 2111051..2111260 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag LB316_RS10390 Protein ID WP_000138934.1
Coordinates 2111272..2111565 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LB316_RS10365 (2106559) 2106559..2107917 - 1359 WP_000611467.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
LB316_RS10370 (2107932) 2107932..2109002 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
LB316_RS10375 (2109320) 2109320..2110522 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LB316_RS10380 (2110786) 2110786..2110923 - 138 WP_000828354.1 Lmo0850 family protein -
LB316_RS10385 (2111051) 2111051..2111260 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LB316_RS10390 (2111272) 2111272..2111565 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
LB316_RS10395 (2111731) 2111731..2113215 + 1485 WP_000571549.1 cardiolipin synthase -
LB316_RS10400 (2113243) 2113243..2113890 + 648 WP_001187619.1 HD domain-containing protein -
LB316_RS10405 (2114804) 2114804..2115676 - 873 WP_000725802.1 membrane protein insertase YidC -
LB316_RS10410 (2115762) 2115762..2116403 - 642 WP_000483165.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T218125 WP_000581792.1 NZ_CP084107:c2111260-2111051 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T218125 NZ_CP115622:c18270-17914 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ACATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAACT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT218125 WP_000138934.1 NZ_CP084107:c2111565-2111272 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT218125 NZ_CP115622:c17921-17619 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References