218123

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1924432..1925208 Replicon chromosome
Accession NZ_CP084107
Organism Staphylococcus aureus strain CC49/ST49-MSSA

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LB316_RS09325 Protein ID WP_000031108.1
Coordinates 1924432..1924584 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag LB316_RS09330 Protein ID WP_001251218.1
Coordinates 1924609..1925208 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LB316_RS09310 (1920512) 1920512..1921333 + 822 WP_000669380.1 RluA family pseudouridine synthase -
LB316_RS09315 (1921793) 1921793..1923178 - 1386 WP_000116235.1 class II fumarate hydratase -
LB316_RS09320 (1923374) 1923374..1923769 - 396 WP_000901022.1 hypothetical protein -
LB316_RS09325 (1924432) 1924432..1924584 - 153 WP_000031108.1 SAS053 family protein Toxin
LB316_RS09330 (1924609) 1924609..1925208 - 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
LB316_RS09335 (1925367) 1925367..1925837 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LB316_RS09340 (1925842) 1925842..1926969 - 1128 WP_000379982.1 tRNA epoxyqueuosine(34) reductase QueG -
LB316_RS09345 (1927120) 1927120..1927842 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
LB316_RS09350 (1927835) 1927835..1929292 - 1458 WP_000649919.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T218123 WP_000031108.1 NZ_CP084107:c1924584-1924432 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T218123 NZ_CP115621:c3478014-3477625 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTCAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCGCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCCATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT218123 WP_001251218.1 NZ_CP084107:c1925208-1924609 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT218123 NZ_CP115621:c3478278-3478021 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACTTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References